, 7 tweets, 2 min read Read on Twitter
There's a company called Homology Medicines saying it can efficiently edit genomes with just a virus (no CRISPR). We wrote about it a while back and aired some questions about the claim. Now there is a preprint saying that it's irreproducible. 1/4
Here's our story about Homology Medicines, aka $FIXX , the company claiming to edit genomes with just a virus. It raised a lot of money and went public in 2018 2/4 technologyreview.com/s/608749/in-a-…
Here is the original efficient-gene-editing-with-just a virus result in PNAS from company's science founder pnas.org/content/115/31…

Here is the pre-print that sought to confirm the results, but did not. 3/4 biorxiv.org/content/biorxi…
Here are some words from the preprint. These arent good words

"Confusingly"
"unable to explain"
"not sufficient to reproduce these results"
"not a universal phenomenon"
"we found no evidence" 4/4
FIXX response in Biocentury: "Homology responds to reproducibility concerns" biocentury.com/bc-extra/compa…
can't behind this paywall, but there is a Stat+ story. Someone tell me if they credit my twitter exclusive statnews.com/2019/07/26/a-r…
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