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@noname_2112 Keep in mind that these postulates were never meant to be taken as some sort of commandment
"The limitations of Koch’s postulates, evident in the 1800s,
are even more pronounced today."
cmr.asm.org/content/9/1/18 Image
@noname_2112 These were formulated in a time before viruses were defined and well before sensitive detection methods existed!
"is unfortunate that so many workers blindly followed the rules, because Koch himself quickly realized that in certain instances all the conditions could not be met"
@noname_2112 Alfred Evans proposed a useful list based on antibodies
ncbi.nlm.nih.gov/pmc/articles/P… Image
@noname_2112 And Zika virus sparked a lot of interest in this area most recently, in interpreting and applying the Bradford Hill criteria (ncbi.nlm.nih.gov/pmc/articles/P…)
e.g. ncbi.nlm.nih.gov/pmc/articles/P… and within other considerations nejm.org/doi/full/10.10…
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