Siebe. Profile picture
May 29 4 tweets 5 min read
#pwME and #LongCovid
If you have taken any antivirals or monoclonal antibodies, please fill in this survey:

hipaa.jotform.com/221391081417046

Options include:
- Tollovid/Gromwell root
- Paxlovid
- Molnupiravir
- Remsdesivir
- Mabs
- Any other antiviral

Data will move us forward!
Note: experiences with no effect/adverse effects are very much welcome!
Note #2: I understood from @jencurtinmd that she's already got a bunch of responses. So imagine if it spreads far!

If you know anyone who tried this, please ask them to fill in the survey

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Siebe.

Siebe. Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @PatientPersists

May 31
@ahandvanish @VirusesImmunity (in hindsight, I could have googled this question 😅 but it's fun thinking publicly!)

So, low NK function: probably part of the picture

I wonder if this is a cause (low NK at acute phase increases risk of chronic infection) or consequence (NK cells working hard but ineffective)
@ahandvanish @VirusesImmunity If it's a cause: why are they low? Previous (chronic) infections? Other immune damage?

And: I suspect there's something going wrong with NK cells' targeting mechanism. Low NK cells alone would be too easy to fix.
@ahandvanish @VirusesImmunity Increased Levels of NK Cells in the Long-COVID Group

The total levels of NK cells, characterized by the expression of the activation marker CD56, were increased 1.7-fold (p = 0.0005) in the Long-COVID group, in comparison with the Recovered group

frontiersin.org/articles/10.33…
Read 8 tweets
May 30
I'm just learning that NK cells apparently kill other cells that fail to express MHC I. Not expressing MHC I is suspicious.

So this question ⬇️ is excellent, not only for acute COVID, but also for #LongCovid .

What's going on with NK function in LC?

@VirusesImmunity
I was sent this excellent post written by @CortJohnson

NK cells in FM:
- are "wired but tired"
- have a specific "profile" (more of some receptors, less of some others)
- are differentially attached to SFN

Maybe a chronic neurotrophic virus causes FM?

healthrising.org/blog/2022/04/2…
The obvious question is of course:

Is TGFbeta higher in long covid?

It doesn't seem so!

medrxiv.org/content/10.110… ImageImage
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(