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Jeremy Sussman @JeremySussman
, 6 tweets, 2 min read Read on Twitter
New migraine drug outperforms placebo, priced at $6,900/year. Placebo?? Drugs for migraine include coffee and aspirin, both effective. The triptans are work well, have minimal side effects, & are cheap. jamanetwork.com/journals/jama/…
Those "with previous treatment failure with 2 classes of migraine-preventive medication were excluded." How is it ethical to test new drugs only in patients who haven't tried existing, safe, effective ones?
Benefit of new migraine drug: Basically 5 migraine days/month instead of 6.5.

jamanetwork.com/journals/jama/…
Essentially, these tweets are the bat-call for @VinayPrasadMD.

And further thanks to my neurology consultant, to whom I owe a beer.
Slight clarification: @icer_review does compare to existing preventive treatment. Cost/qaly goes from dominated to as "low" as $466K/qaly.
So per @icer_review, these drugs should only be used in patients who fail multiple classes of preventive drugs. At the same time, those patients were excluded from the drugs’ trials. Disappointing situation.
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