Genetic research and seeker of truth. gab: @Flavinkins
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May 25 • 13 tweets • 6 min read
@scotub These are actually not class II MHC epitopes—they are so-called “CTL epitopes” (or MHC class I epitopes) which are in fact dominated by pentapeptide and hexapeptide fragments. The long peptide view only hold for CD4 T cell epitopes, and even with that partial homology still
@scotub Dominate reactivity—only the central part of the peptide which is usually 8 to 12 AA in length contact the TCR from a CD4+ T cells. As for CD8+ T cells, their epitopes are much shorter—same as the linear B cell epitopes which are also on average 6-7AA in length and are
@Biorealism Also RC-O319 is more distant than ZC45, and RahSTT182/200 have A singly deleted RBD making them unrelated to SARS-CoV-2 by the RBD. drive.google.com/drive/folders/…
And thus incapable of becoming an ancestor (not hACE2-RBD. Variable loop 1 deleted).
@Biorealism Rc-O319 is a loop 2 deleted RBD.
And a single case before and outside the market disproves the market. There are at least 2 cases in Italy and 1000 cases in Brazil (minimal number required to turn wastewater PCR positive) in November 2019 a month before the market.
Market origin is
Completely incompatible with any presence of SARS-CoV-2 before the initial cluster at the market in a place other than the market—and we get at least 3 independent confirmations of such presence of the SARS-CoV-2 virus in samples predating the outbreak at the market, outside the
May 18 • 14 tweets • 7 min read
@Ayjchan And the ones who was manufacturing a consensus publicly was also voicing privately opinions and concerns that were completely opposite of what they claim to be “scientific consensus”.
And don’t like that sometimes like this did happen before. See the E.Coli O104:H4 outbreak in Germany, which was falsely attributed to contaminated tomatoes on the organic produce market and the farms that supplied them. Only after further investigation of
If you want to trace back cases, the very first batch of cases (positive environmental samples and positive swab samples) are completely unrelated to the Huanan market—in fact, they were outside China and were on different continents than where bats with
Markolin ignored selectively every genome that have just 8782C, which is plenty in Wuhan, Beijing and constitute 1/6 of all genomes
In Sichuan, Ignored cases before Huanan which exist even outside of China since 10/11/2019. archive.ph/0RLCs
Markolins failed to consider the existence of severe Bias in the way the first cases were reported to the WHO. archive.ph/MCqMS
@breakfast_dogs@jbloom_lab@ydeigin datasets can be contaminated, and unless the exact cause for deletion have been public and the exact info (metadata, origin, institution, study type, country) have been released and verified to be not related to SARS-CoV-2 or have a potential of being contaminated with it before
@breakfast_dogs@jbloom_lab@ydeigin the pandemic (e.g. in the same location as high-risk labs studying coronaviruses and GOF), the datasets can not be simply casted aside as "not SARS-CoV-2". remember that contamination by SARS-CoV-2 of data, even unrelated data, can be the cause of retraction especially for
The most inconvenient fact is that there are cases of SARs-CoV-2 verified infections and verified positive wastewater samples before the market and 6000+ km away from the market. In a real scientific debate it rules out the market completely.
SARS-CoV-2 is broadly immunogenic and provide protection against severe disease to SARS-CoV and other Sarbecoviruses. More recent isolates like Omicron (no longer cleaved on the S1-S2) seems to begun recovering ADE capacity……