Yardley Yeadon Profile picture
BSc biochem tox, PhD respiratory pharmacol. 32y new meds research. Left Pfizer 2011 as VP Respiratory. 2012 founded biotech Ziarco, sold to Novartis 2017.
President Presumptuous Ƒʉͫcͧкͭιͪηͣ 3TW 🐙 Profile picture County Assembly Profile picture MidNight*Rider Van Storm Profile picture Scott Robert Profile picture VJPCanAmer Profile picture 87 added to My Authors
28 Nov
@Cakefac87136984 @lyne_ian @uksciencechief We don’t, with the exception of for the most vulnerable. If a safe & effective vaccine becomes available it should be offered with fully informed consent. But careful: typically the oldest & most vulnerable are in this position because their immune systems don’t fight viruses...
@Cakefac87136984 @lyne_ian @uksciencechief ...so well. But that also applies to vaccine induced immunity too. The oldest often derive least benefit from ‘flu vaccines too. And early vaccine trials usually exclude subjects of great age. So you end up with little to no data about safety & efficacy in the pop you most want..
@Cakefac87136984 @lyne_ian @uksciencechief ...to protect. It’s a conundrum without solution. It’s where we are now. In my view, no one else needs, should consider or be offered vaccination against this virus because the risk of severe illness is slight compared, for example, with ‘flu. If you wouldn’t seek a vaccine...
Read 26 tweets
24 Nov
Watching M. Macron. We’ll soon be able to travel further from our home than 1km. Hurray for Liberté! But have to be inside again with 3h. Though we’ve not found the police to be officious, like everyone, we’re nervous of being caught beyond the terms of our passes (attestation).
They’re moving to ever-increasing levels of mass testing. Isolation of cases & contacts “will be made more binding”. What can this possibly mean? As in U.K. we’re already required to self-isolate. “Vaccination will not be mandatory, but will be made at a mass scale...
...and we will recruit & involve citizens to ensure this is done equitably & openly at all stages”. You join the dots.
The US has a famous medical journal, the New England Journal of Medicine. I recall as a young scientist being thrilled at taking a photocopy of an article in...
Read 20 tweets
23 Nov
I’ve asked SAGE if they would kindly deposit in the public domain the trove of information they’ve used to create their model relating to the so-called “2nd wave”. I ask because I can’t find any foundational literature on this field. Just post-WW1 stories. There is surely much...
...more. Where is it? I think most people would expect that the premier team advising Govt is using more than Wikipedia to inform their “2nd wave” model? So what published scientific literature are they resting their predictions upon? If they will not share this, I conclude...
...that they’ve no such evidence for “2nd waves”. I’m asking because I’m unaware of any scientific principles or medical experience relating to such ‘waves’. There’s some seasonality, but that’s not what SAGE means. Theirs has a peak in spring & total lethal impact twice as...
Read 7 tweets
23 Nov
@Microbedoc2 @Dr_HarrieB @abusy_mind @DrDJWilde @LeahButlerSmith @DrBruceScott @honestjonberry I think I can help you. The heart of this is immunology & I’m highly qualified there. There were no immunologists in SAGE in spring. The one on it now has forgotten his teachers lessons. We know this because Ivan Roitt was also my ‘teacher’. He wrote the course text.
@Microbedoc2 @Dr_HarrieB @abusy_mind @DrDJWilde @LeahButlerSmith @DrBruceScott @honestjonberry In addition to being demonstrably far more qualified in immunology than anyone on SAGE (with the notable exception of Patrick Vallance, perhaps, who’s also forgotten his immunology), I have decades of experience in mass testing. How do you think we find chemical starting points?
@Microbedoc2 @Dr_HarrieB @abusy_mind @DrDJWilde @LeahButlerSmith @DrBruceScott @honestjonberry Finally, I have a solid understanding of the principles underlying risk / benefit, as this features heavily in any decision to continue with clinical development. So it is clear that nothing Govt has done since before the start has helped, but has definitely resulted in huge...
Read 11 tweets
21 Nov
This is great. The first time the notion of “asymptomatic transmission” was mentioned, I smelled a rat. It’s biologically implausible. Not saying it’s never happened once, but as an important contribution to transmission? No. To be a source, you need lots of virus in your...
...airway. But once that happens, you will be symptomatic, either because the virus is injuring your lung lining (epithelium) or because you’re fighting it off (or both). You can’t be both a virulent source AND not have symptoms. Yet it was on the basis that you often wouldn’t...
...show symptoms yet place others at risk that MASS TESTING, all the time, in ever-increasing numbers, was commenced. Now we formally know what basic biology & immunology told us, we can HALT MASS TESTING OF THE ASYMPTOMATIC. We’ve said it for months. Mr Hancock, stop it now.
Read 5 tweets
21 Nov
In large measure, I’m telling you this so that you should be in no doubt that:

MANY MPs NOW SHARE THE VIEW THAT CLARE CRAIG FRCPath & I ARE DAILY SUMMARISING HERE.

Obviously I mean also those many other helpful, clever people with insights about prior immunity, PCR testing...
...flaws, results from LFT testing, nature, number & causes of excess deaths, the persistent cruelty of useless & redundant ‘lockdowns’, mask mandates & illegal restrictions. How dare they tell you that you must do this & that you must not do that?
The MPs are the people who voted to renew the Coronavirus Act (2020) on or close to Sept 30th. Almost all of them did. 7 Tories voted against & we’d briefed 4 of them. Bone, Davies, Hollobone, McVey, Swayne, Walker & Wragg. 6 Lab MPs voted against: Long-Bailey, Butler, Jones,
Read 6 tweets
21 Nov
A bit of feedback from recent discussions I’ve had with Westminster MPs. One who I won’t name said “Mike, you’ve moved from being a somewhat fringe figure to being mainstream & in the vanguard”.
Put another way: numerous MPs know of & agree with my position on the virus.
Isn’t that great? I don’t know how many MPs hold this view, but Clare Craig FRCPath & I, who hold fundamentally the same view, have each briefed a decent handful of people & of course they talk (& we always give them a reading list). I’m guessing we’re looking at a few dozen.
The very bad news is: they’re not going to do anything because they’ve no power. None of them can speak to Hancock or the PM. Their calculus is Dec 2nd is a lost cause (because Labour wouldn’t put Boris out if he was on fire) but maybe they can have a crack in mid-January.
Read 4 tweets
20 Nov
Quarter of people may already be immune to coronavirus..
I’m delighted that mainstream newspapers are picking up on ‘prior immunity’. It’s a lot more than 25%, arguably >50%. 1st paper MID-APRIL!! It’s normal & expected. Only Q, how much. SAGE said zero. telegraph.co.uk/news/2020/11/1…
In my paper, “What SAGE got wrong” I simply pointed out they’d erred badly & unaccountably. Vallance & I share a educational & work history. He knows what I know.
So why does he persist in misleading the PM & public?
I now think prior immunity was 50% but % infected lower at...
15-20%. Net effect is HERD IMMUNITY. I was right months ago & respectfully I submit I’m right now, too.
But if we’re at HI, it’s impossible to have the National outbreak, this 2nd wave, that we’re told is happening.
lockdownsceptics.org/what-sage-got-…
Read 17 tweets
17 Nov
Thanks JE! Up to date info, total weekly deaths, which are very close to normal for early Nov. I say again: you can’t have a lethal pandemic stalking the land yet not have excess weekly deaths. The explanation: we’re in a PCR false positive pseudo-epidemic. If anyone wants to...
...do battle & claim there are excess deaths, once adjusted for population change, there’s little to nothing. And can’t you think of an explanation that isn’t covid19? Restricting access to NHS for a population for 8mo & counting will lead to avoidable non covid19 deaths. This..
...pandemic was over in June or earlier, due to herd immunity, reached quickly because half of us already had prior immunity. We’d been infected by common cold causing coronaviruses, so cross immunity, like cowpox/smallpox & the very invention of vaccines.
Everyone surviving...
Read 7 tweets
15 Nov
Were MPs given full information about claimed (unusual) stresses on the NHS before the vote on LD#2?
ICU loadings weren’t unusual for time of year (as I told you, 81%. Turns out it was 79%). MPs not told.
Oxygen use entirely normal. MPs not told.
No excess deaths. MPs not told.
Crucial adjustment to deaths data: adjustment for population. Thanks TheStatsGuy. So not only no excess respiratory deaths which I’d been flamed for (correct,but MPs not told) but with this view, no excess deaths at all. But we’ve had thousands of covid19 deaths recent weeks.
The resolution is thousands of normal deaths (620,000 each year in U.K.) are wrongly coded Covid19 to scare you. That happens because the pitifully poor mass PCR test generates immunologically unfeasible nos of positive results. Meaningless without the operational FPR. Govt...
Read 4 tweets
15 Nov
@earnestobob @MLevitt_NP2013 This isn’t as big a surprise as I’m sensing. If you’ve seen a related immunogen, you’ll have T-cells responsive to epitopes (short peptides) in common between the old immunogen & a new but related one. Several papers have proven this occurred between common cold causing CoVs &
@earnestobob @MLevitt_NP2013 ...SARS-CoV-2. I confess I haven’t explored the corollary on the antibody side but in principle the same could apply. I haven’t looked because it’s the T-cells that dominate responses to most viruses & respiratory viruses. On T-cells I’m aware of at least 7 full papers showing...
@earnestobob @MLevitt_NP2013 ...very substantial immunity (T-cell responses) to SARS-CoV-2 in prepandemic leukocytes.
A recent paper showed 81% of subjects having this distinct recognition. Again, epitope analysis demonstrated the shared origins as common cold coronaviruses. I mused that if there’d been...
Read 7 tweets
14 Nov
I demand we halt mass PCR testing. Everyone should campaign for this. It’s the single action needed to save our society.
1. It’s untrustworthy. Govt admits it’s out of control: basic QC hasn’t been done, ever. If was a diagnostic test in the NHS, it would immediately be stopped.
2. It’s not necessary. Track, trace & isolate might once have been useful but it’s proven to be a hopeless flop. It finds few contacts & far too late. Only a small minority of contacts are reacted. Of those contacts, 90% don’t do what was asked of them. It helps no one.
3. It only causes damage. Because of a positive test, almost all of which now aren’t of live virus, it damages lives & livelihoods for no gains. “Cases” aren’t true but drive lethally bad adaptations like restrictions to NHS, leading to excess deaths.
Read 10 tweets
13 Nov
@elonmusk Elon, there isn’t one answer to this. It depends among other things on the number of tests run per day as a measure of stress on the testing system. Most false positives arise from handling errors in the sample processing stages. In U.K. I’ve seen test runs yield >10% positives.
@elonmusk This is on people who weren’t symptomatic. I’m happy to be corrected, but I don’t think we ever got to 10% positivity in the population at the height of the spring pandemic.
If correct, it’s then certain that such PCR runs are completely unreliable.
@elonmusk I’m a scientist & love cool techniques like PCR which can do things that are almost impossible in other ways. But features giving PCR awesome powers also make is non-robust in a production context. For some reason, too few are aware it’s possible to have all positives be false.
Read 16 tweets
12 Nov
@chicago_sunrise @subsix848 @AlexBerenson @JAMA_current Strictly you can’t culture (grow in isolation) a virus. They only grow if they can invade living cells. So that’s what we mean: “can you infect susceptible cells using a clinical sample?”
In this paper, the answer is no, in patients whose PCR was only positive if amplification...
@chicago_sunrise @subsix848 @AlexBerenson @JAMA_current ...is turned up high. If other words, if your sample is PCR positive only when amplification is turned up beyond 32 cycles, THEY ARE NOT INFECTIOUS.
Once we learned this, early in the spring outbreak, I bet you all think there was broad agreement that we’d set the maximum...
@chicago_sunrise @subsix848 @AlexBerenson @JAMA_current ...amplification to 32 cycles, if you’d hope so, if there were any honest scientists doing this work.

They did no such thing. In U.K. they’ve kept the amplification turned up to FORTY (40) cycles, even AFTER it’d be repeatedly shown that positive results obtained at more than...
Read 11 tweets
10 Nov
@d_spiegel @LettingFocus @SeanBFlanagan @BreesAnna @toadmeister @allisonpearson @ClarkeMicah @Charlotte3003G @MLevitt_NP2013 @SunetraGupta @carlheneghan @MartinKulldorff @AlistairHaimes @FatEmperor @HaraldofW @JuliaHB1 @Iromg @talkRADIO @mgmgomes1 @spectator @unherd @freddiesayers @spikedonline @ProfKarolSikora @HuwMerriman Respectfully, that’s incorrect, Sir David. I bow to you as master statistician. I ask that you recognise there is a great deal of laboratory insight I have that affects the outcome & isn’t amenable to statistical analysis if you’re unaware of these.
Just as a simple example...
@d_spiegel @LettingFocus @SeanBFlanagan @BreesAnna @toadmeister @allisonpearson @ClarkeMicah @Charlotte3003G @MLevitt_NP2013 @SunetraGupta @carlheneghan @MartinKulldorff @AlistairHaimes @FatEmperor @HaraldofW @JuliaHB1 @Iromg @talkRADIO @mgmgomes1 @spectator @unherd @freddiesayers @spikedonline @ProfKarolSikora @HuwMerriman ...the manufacturer’s values for false positives is under ideal conditions & measure the intrinsic limits for example the ability under perfect conditions to distinguish some sequences from all others. This isn’t the main source of false positives at all. These are mostly...
@d_spiegel @LettingFocus @SeanBFlanagan @BreesAnna @toadmeister @allisonpearson @ClarkeMicah @Charlotte3003G @MLevitt_NP2013 @SunetraGupta @carlheneghan @MartinKulldorff @AlistairHaimes @FatEmperor @HaraldofW @JuliaHB1 @Iromg @talkRADIO @mgmgomes1 @spectator @unherd @freddiesayers @spikedonline @ProfKarolSikora @HuwMerriman <lost my place & fell asleep, it’d been a long day>
...caused by issues related to the sample itself (eg biologically they’re very ‘dirty’ & may contain very large amounts of irrelevant bacterial DNA) and / or sample preparation. I use as explainer the comparison of the person...
Read 24 tweets
8 Nov
Assuming this advert from an estate agent is correct, the housing market remains open during LD#2.

”We are open and here to help in the safest possible way.
In line with latest Government’s guidelines on home moving, the housing market will remain open during the national...
... lockdown which started yesterday, the 5th November 2020, and all our offices in England will continue to operate.
 
Exceptions on leaving home include undertaking any of the following activities in connection with the purchase, sale, letting or rental of a residential...
... property:
 

Visiting estate or letting agents, developer sales offices or show homes

Viewing residential properties to look for a property to buy or to rent

Preparing a residential property to move in

Moving house

Visiting a residential property to undertake...
Read 33 tweets
3 Nov
@berniespofforth Honestly, is the world so full of people who can spend all day on the net, but can’t find a half hour to peruse a simple, immunology text?
It’s not an edgy view to suggest that, having survived infection by a simple, non-immunotoxic, epitope-stable virus, that robust, durable...
@berniespofforth ...immunity follows, is the general rule, not in any way the exception. It’s not conveyed mostly by antibodies, though such titres are sometimes raised, but through memory T-cells. This is why cellular immunologists knew exactly what studies to run on representative samples of...
@berniespofforth ...stored blood, as soon as then knew what was coming round the globe. Those techniques aren’t easy, technically, but they’re well established. We even ran analogous studies maybe 25y ago in a new drug program. First full papers were out on this topic mid-April, IIRC.
No one in..
Read 9 tweets
2 Nov
@CJforeveryoung @grahambradymp I’ve briefed him in writing in a ‘one pager’ as I guessed he’s too busy to read more than an ‘executive summary’.
He replied ‘thanks’ but it was probably his office manager.
I’ve briefed 16 MPs personally, one 4x in one day! (He kept calling to check one more thing!). One...
@CJforeveryoung @grahambradymp ...other MP called me at home two weeks ago. They agreed to file a series of written Qs. So I wrote a series of tightly worded Qs to Mr Hancock re PCR testing & to the Cabinet Sec (to whom SAGE formally reports according to a friend in Public Law). I’ve not been told we’ve..
@CJforeveryoung @grahambradymp ...any answers yet. I’m told they’re taken v seriously in Hansard so in due course they have to answer. But so long as they’re not obviously evasive & haven’t lied, it gets you nowhere.
I see someone recently asked about “PCR false positives” but failed to time-bound the Q. So..
Read 4 tweets
2 Nov
COVID-19: Do We Have a Coronavirus Pandemic, or a PCR Test Pandemic? - AAPS | Association of American Physicians and Surgeons

I’m not alone is completely distrusting current PCR mass testing.
“Coronavirus is not a pseudo-epidemic... aapsonline.org/covid-19-do-we…
... epidemic. Many thousands have died. But the dreaded “second wave” might be a surge of false positive tests that are inevitable in mass screenings of healthy persons.

The CDC limits the primers and probes that may be used for PCR testing. For the viral sequences that may...
... be used for viral surveillance and research, the CDC posts this disclaimer on its website, cdc.gov: “Every effort has been made to assure the accuracy of the sequences, but CDC cannot provide any warranty regarding their accuracy.”

It’s not only primers...
Read 17 tweets
1 Nov
@BreesAnna Please read my very accessible review of the pandemic here:
lockdownsceptics.org/what-sage-got-…
Nothing here is my speculation. All drawn from peer reviewed journals or work in review by worlds top immunologists & epidemiologists.
@BreesAnna Since writing this I’ve come across several anomalies in the public record.
1. Virtually no excess seats since July.
2. NO EXCESS RESPIRATORY DEATHS since July.
These are inconsistent with SAGE’s claim that a full blown pandemic continues.

I’ve worked in mass testing. It’s...
@BreesAnna ...very easy when using a genetic material amplification technique (PCR) to inadvertently ‘find’ things that aren’t there. Hence when used in forensics, there are often legal / technical arguments about admissibility.
Rather than try to explain how “false positives” occur, I...
Read 13 tweets
31 Oct
In U.K. in spring there was an v strong relationship between covid19 deaths & excess deaths. Correlation isn’t causation but it’s strong evidence - in spring - that the one is responsible for the other. In formal terms it’s consistent with that hypothesis. We’d expect it, too.
In recent weeks this has completely broken down. It’s no longer possible to stand up the claim that covid19 deaths & excess deaths are causatively linked. In formal terms the data are not consistent with the hypothesis that covid19 deaths are the cause of any excess deaths.
I forgot to say, the most likely explanation for this inconsistency is that our measurements are wrong.
The PCR test for Covid19, like all such tests, is capable of ‘producing a misdiagnosis’.
Technically we call it false positives. When a testing system is overstretched and...
Read 57 tweets