Most studies examine blood as a means for assessing SARSCOV2 immunity. This study examined tissue resident immunological memory in seropositive organ donors. They found lungs and lung lymph nodes were the most prevalent sites for memory T and B cells, science.org/doi/10.1126/sc…
They identified 4 organ donors ages 10-74 years with previous infection who died of non-infectious-related causes and were SARS-CoV-2 PCR negative at the time of organ procurement.
They examined SARSCov2 specific T and B cell responses across blood, bone marrow, spleen, lung, lung-associated lymph nodes and gut-associated lymph nodes of seropositive and seronegative donors.
Maybe the spike activates platelets (via calcium release), membrane exchange of PS and raising milieu for hypercoagulation. Ppl w anti-PF4 Abs (either ppl who already have it or vaxx induced) see a nucleating particle on cell surface of platelets that initiates the process .
The plasma distribution of the vaccine (it floats around in plasma vs distributes to tissues) & anionic property of DNA (instead of heparin anion) binds PF4 and itself nucleates the clustering of PF4/Fc receptors and leads to these unique disseminated venous thromboses
This emerging data is responsible for the rift in the “vaccines are miracles” United front of the “experts”. Fauci knows we are on a cusp here w burgeoning data yet to be made public - see bottom panel month >=7 months
If I see it so does he and they need to act quick and gather their forces together in raid alignment . The wheels are falling off
Ok another question. Please explain to me why the vaccine might ultimately be shown to be inferior to no vaccine in this study beside the usual refrain of vaccines are bad/evil bioweapon, ADE and evolution of more immune evading dangerous variants. I want to see who is learning
Despite the high vaccine coverage, the incidence of SARS-CoV-2 infection increased slowly from July to August 2021, before starting to decline at the end of August
Effectiveness against infection declined gradually, starting from the first month after the second dose. The decline accelerated after the fourth month, and effectiveness reached a low level of approximately 20% in months 5 through 7 after the second dose.
@DaviJones52@luigi_warren Contradicts what, the graph i posted? This is one of the few (only?) papers I've seen looking at Ct over time (early to late in illness) presented by vaccination status.
@DaviJones52@luigi_warren One needs to keep in mind the caveats around Ct though, as i've explained to you before. No doubt there seems to be a very large different btwn the groups w/re to rate at which viral loads decrease in vaccinated vs not (in vaccinated favor)
@DaviJones52@luigi_warren But the high viral loads early on in vaccinated (during the critical Day 1-5 period where they see the most interpersonal transmission) is noteworthy and goes along w my hypothesis about ADE boosting in oral/nose/throats of vaccinated
here's another testable hypothesis which will go untested.
The study revealed that 97% and 93% of participants were positive for anti-spike IgG and IgA, respectively, two weeks following the first dose, and that 52% and 41% were positive for anti-RBD IgG and IgA antibodies.
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity nature.com/articles/s4146…
Next narrative up... prior immunity to sarscov2 doesn't protect you from lethal disease if you're coinfected w influenza. They'll be milking this angle endlessly. Just wait.
Only prior immunity to influenza can save you from lethal covid if you're coinfected w influenza/covid (even if you have immunity to covid). You need both shots, don't you see? You need to be boostered against covid and immunized against the flu.
We have to remember here that the mRNA spike constructs can transfect stem cells (megakaryocytes/platelets, myeloid stem cells/RBC) in bone marrow before forming platelets and RBC. So the spike protein can be expressed within these cells even though they do not have nuclei.
Also, remember, due to the long-half life of platelets/erythrocytes (7-10 days and 2-12 weeks, respectively), it will take some time before healthy, non-spike expressing platelets/erythrocytes are removed/turned over within the body.
Thus, a palmitated spike protein in these cells will remain at the cell surface in lipid rafts (interacting with other proteins there and stimulating signal transduction pathways) and be relatively slowly turned over/degraded
thereby enhancing syncytium formation/fusion
Excellent up-to-date review article on the involvement of the S protein in forming syncytium and the deleterious effects thereof. A few noteworthy points intermixed w a few thoughts of my own
You know what jumped out at me while reading this paragraph? Yea, the kinetics and intracellular distribution/localization of the spike protein in mRNA vaccine transfected cells is much different vs virally infected cells. More cell surface vs intracellular. Oops!
There's no M or E protein in mRNA vaccine transfected cells to retain the S protein in intracellular compartments so it effluxes to the cell surface after meeting with furin in the Golgi and getting itself clipped up and ready for promoting cell-cell FUSION
Betwn Dec 14, 2020-Aug 8, 2021, of 3.5 mill fully vaccinated individuals, effectiveness against infections was 73% and 90% against hospitalization. Effectiveness against infections declined from 88% during 1st mo to 47% 5 mo post-vaxx. thelancet.com/journals/lance…
Vaccine effectiveness against infection for the fully vaccinated decreased with increasing time since vaccination, esp in ppl >65 years but protection from hospitalization remained durable across all ages
Overall vaccine effectiveness against infection with the delta variant for the fully vaccinated was 75%, while overall vaccine effectiveness for other variants was 91%. The difference in rate of decline in vaccine effectiveness between delta & other variants was not significant
It is beyond doubt that natural infection results in a potent and durable humoral and cellular immune response. But, yet, natural infection is not granted proper consideration/respect in the public safety guidelines. mdpi.com/1999-4915/13/1…
Not all neutralizing antibodies function by blocking interaction btwn ACE2 and RBD of spike. This non-RBM neutralizing Ab isolated from a CONVALESCENT induces S1 shedding from the S trimer and blocks syncytia formation.
We need this monoclonal as a therapeutic!
They should give this monoclonal to people after they give them updated mRNA gene therapy
This paper compared antibody titers (to SARSCOV2 spike and common seasonal CoV) before and after natural infection vs 2 doses pfizer to address the question of "original antigenic sin". A few points medrxiv.org/content/10.110…
First, it should be noted that the "natural infection" cohort consisted of people w mild infection who participated in serology surveillance study. Only one post-seroconversion time point/samples were taken and may not represent the maximal effect.
Prior studies have shown that the breadth and affinity of antibodies continue to evolve in convalescents post-infection up to 1 year after infection. Of course, this wasn't addressed here in this study. Nope, just one time point soon after infection (not specified when exactly)
The Mail on Sunday requested emails, minutes and notes re the call between Sir Patrick Vallance and its organisers (Farrar, Fauci). Yet when the documents were released they had page after page redacted. dailymail.co.uk/news/article-1…
👀I don't recall seeing this input/analysis from Andersen before