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@KidneyAide @sbABetterLeader @AnnaGaddy @IUKidney @hswapnil Quick tutorial on oral urea. Urea is used for hypoNa bc urea excretion requires H20 excretion (without Na) and thus ⬆️ electrolyte free water clearance (EFWC) which ⬆️ [PNa] in pts with ⬇️ EFWC (most commonly SIADH).
@KidneyAide @sbABetterLeader @AnnaGaddy @IUKidney @hswapnil 2) Urea has a molecular weight of 60 (60 gram/mole = 1000 millimoles and urea has no charge so that is 1000 milli-osmoles/mole (mosm/mole)). The commercial products are sold as 15gm units (1/4 of a mole) = 250 mosm.
@KidneyAide @sbABetterLeader @AnnaGaddy @IUKidney @hswapnil 3) The average pt excretes ~750 mosm/day so adding 250 mosm allows third more of water intake/d, 30 gm 2/3 increase, and at 45 gm pt can double water intake.
