Discover and read the best of Twitter Threads about #longСОVΙD
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More caveats about the COVID-OUT of Metformin for #longСОVΙD. The benefits of Metformin were diminished by vaccination but it was only taken for 14 days (“500 mg on day one, 500 mg twice daily on days 2–5, then 500 mg in the morning and 1000 mg in the evening up to day 14”).🧵 
There are plenty of studies of viral persistence, showing the ongoing presence of replication-competent virus for many months after the acute illness. In chronic hepatitis C, we treat with antivirals not for 2 weeks but for 12 to 24 weeks!
The BMJ editorial also states, “Other arms of the trial looked at…fluvoxamine and found that [it did not decrease] the risk of long СОVΙD.” That should say, “looked at a subclinical dose of Fluvoxamine” and found it didn’t work. A half-dose of Metformin probably wouldn’t either.
