I'll be talking about how genomics might offer clues to design new treatments for sepsis at #WCIC19. Ultimately this needs global effort, led by local clinicians: download our free, open-source research protocol here: genomicc.org
This work is generously funded by @stopsepsisnow , @wellcometrust and @icsupdates
@stopsepsisnow @wellcometrust @icsupdates This reference summarises the main approach we're suggesting. Patients don't fall into mutually-exclusive categories. We need to move away from phenotypes and focus on identifying treatable traits research.ed.ac.uk/portal/files/3…
@stopsepsisnow @wellcometrust @icsupdates And, for those who like this sort of thing, the effective shunt calculator is here baillielab.net/es
@stopsepsisnow @wellcometrust @icsupdates Finally, Lucile Neyton's excellent work, providing the first evidence that critical illness sub-phenotypes are generalisable across different syndromes (pancreatitis and ARDS in this case) is free and open access here: biorxiv.org/content/10.110…
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