Abs 694: Dr Puiz presents GEM-Claridex trial of Rd vs Clarithromycin-RD. Got to witness Sweet moment at end when her mentor @mvmateos flashed her the “Great job, my protege!” smile we all need to see ❤️
GEM-Clarieex provides another cautionary tale about a myeloma regimen that is more effective but more toxic in older patients #geriheme....
Very inclusive with pts into their 90s. Significantly greater CR, >=VGPR rates. We should celebrate 🎉 right? But....
No difference in PFS overall despite better responses in clarithro-Len-dex group. Why? Let’s look at those pts over 75 years: ugh-oh. PFS lower with experimental group than Len-dex control... #geriheme
This is due to more infectious deaths in clarithro-Len-dex arm. Clarithro increases AUC of dex essentially giving higher dose dex. Mirrors what @VincentRK showed in 2010: higher dose dex kills older patients.
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