Digital spatial profiling (DSP) is a rapidly growing biological technique combining genomics, optics, and pathology. Previously, researchers manually examined stained tissue slides or used IHC, an approach lacking in scalability and uniformity.
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DSP protocols allow researchers to barcode tissue regions of interest, analyze them quantitatively, and detect intercellular phenomena with stunning clarity. When combined with #NGS data, DSP should accelerate our understanding of immune-oncology.
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Readcoor recently unveiled its RC2 platform at the Advances in Genome Biology and Technology (AGBT) conference. The RC2 workflow is vertically integrated, inclusive of consumables, hardware, and a cloud ecosystem that can flex data to other bioinformatic suites.
Based on a 2015 Nature article, we believe RC2 uses a modified derivative of the SOLiD sequencing chemistry originally developed by Life Technologies. This feature ostensibly eliminates the need for customers to purchase two instruments (DSP and NGS).
nature.com/articles/nprot…
However, we also think most users will already have access to an NGS instrument (on-prem or core), so it remains to be seen if a combined instrument will emerge as an advantage in a space that is rapidly growing more competitive.
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