Ever wonder how the BCG (Bacillus Calmette–Guérin) vaccine works against bladder cancer?🤔
BCG vaccine➡️approved for the tx of bladder cancer in 1990⌛️
✅Main intravesical agent shown to⬇️risk of progression of non-muscle invasive to muscle-invasive disease (>platinum chemo!)🤯
So, how does a vaccine for MYCOBACTERIUM work for bladder cancer!?🤨(dont worry, I was making the same confused face you are! Let me explain it to you!)
BCG=attenuated live strain of Mycobacterium🦠 bovis (which interestingly is related to the bacteria that causes tuberculosis)
It is administered by DIRECT instillation into the bladder and the mycobacterium outer membrane binds to a substance (Fibronectin) that is ALSO found within the urothelium.
The BCG mycobacterium components are internalized into the urothelial cells and the innate immune system activates a “war zone”⚠️ of inflammatory cells to fight off the attenuated mycobacterium while ALSO fighting the tumor cells the BCG invaded! (How cool!🤯)
Learn more here!
ncbi.nlm.nih.gov/pmc/articles/P…
#Twitterrx #oncopharm #pharmpearl
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