Interesting.
ncbi.nlm.nih.gov/pmc/articles/P…
Some references for the hypothesis that post-acute COVID-19 might be partly an endocrine disorder.
Note treatment for Addison's disease is often corticosteroids as well.
Tangential
medicalxpress.com/news/2017-02-a…
Summary of SARS study above:
nature.com/articles/ncpen…
Broader review article on impact of COVID-19 and SARS on the endocrine system. Latter generally more severe, but appears qualitatively similar.
pmj.bmj.com/content/96/113…
ACE2 expression is consistent with susceptibility of adrenal and thyroid glands and gonads.
idpjournal.biomedcentral.com/articles/10.11…
Same for TMPRSS2. Suggestive, given this enables rapid direct viral entry at the cell surface.
biorxiv.org/content/10.110…
Thyroid damage in SARS autopsies.
ncbi.nlm.nih.gov/pmc/articles/P…
Ischemic adrenal damage, thyroid inflammation in fatal COVID-19.
thelancet.com/journals/lanmi…
Similar adrenal damage:
birpublications.org/doi/pdf/10.125…
ajtmh.org/content/journa…
Adrenal crisis case report:
jmedicalcasereports.biomedcentral.com/articles/10.11…
.
Cross-referencing earlier note on evidence for thyroid damage.
This and preceding appear more likely in moderate to severe cases, though keep in mind many younger people have tried to stay home through even moderate cases (often intermittent ER visits).
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