Is the SPIKE protein wrong target for vaxs?
• Unbiased screen found 29 "shared epitopes" that were main targets for T-cells
• Notably, only 3 of 29 epitopes were located in spike protein
• Most epitopes were located in ORF1ab / nucleocapsid protein
cell.com/immunity/fullt…
Anyway
"Frequent BACTERIAL infections of respiratory tract are often a harbinger of ANTIBODY disorders"
"Respiratory VIRAL infections are more significant in patients with T-CELL immune deficiencies"
So why do virtually all vaxs target SPIKE PROTEIN?
ncbi.nlm.nih.gov/pmc/articles/P…
Also may be very serious
ncbi.nlm.nih.gov/pmc/articles/P…
Conclusion - vaccines should target T-cell responses, focusing on ORF1ab / nucleocapsid protein.
A thing to think about's ADE - antibody dependent enhancement
I've heard that targets other than Spike might be dangerous - although I'd expect it to be the other way around - Spike most dangerous
Does anyone know about this in relation to SARS-CoV-2?
en.wikipedia.org/wiki/Antibody-…
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