Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
View Regular
Siba El Hussein, MD Profile picture
Siba El Hussein, MD
@SibaElHussein
Guest editor @Cancers_MDPI contribute here➡️ https://t.co/LxEbwiFktU | Google scholar https://t.co/Ewe7eFhYRf | @ASCP_Chicago 40 under forty | @uvmvermont

Nov 30, 2020, 5 tweets

(1/5) AML with NPM1 mutation ⬇️

Characteristically prominent nuclear invaginations imparting a “cup-like” or “fish-mouth” morphology, with very strong MPO positivity 🔬

@KirillLyapichev @sanamloghavi

#hemepath #hemepathMDA #PathTwitter

(2/5) Cytoplasmic staining of NPM1 protein by IHC is predic­tive of NPM1 mutations

#hemepath #hemepathMDA #PathTwitter

(3/5) This is because NPM1 mutations cause loss of the nucleolar localization signal and addition of a nuclear export signal, leading to increased protein export from
the nucleus and aberrant accumulation in the cytoplasm

#hemepath #hemepathMDA #PathTwitter

(4/5) On flow cytometry analysis, AML with mutated NPM1 is characterized by high CD33 expression and variable
(often low) CD13 expression

#hemepath #hemepathMDA #PathTwitter

(5/5) In addition, KIT (CD117) and CD123 expression is commonly seen and HLA-DR is
often negative

#hemepath #hemepathMDA #PathTwitter

Share this Scrolly Tale with your friends.

A Scrolly Tale is a new way to read Twitter threads with a more visually immersive experience.
Discover more beautiful Scrolly Tales like this.

Keep scrolling