Thread by @MonicaGandhi9

Wanted to put all real-world effectiveness data for you on the vaccines together in a thread with slides so you can see where we are in the world- have come long way from our clinical trial data table with all of this real-world date.

Data from Israel Ministry of Health released by Pfizer press release on March 11, 2021

Data from Israel and the UK

Data from nursing homes here in the US (CDC)

Health care workers in US with vaccination despite winter surges

CDC data from March 29

And Pfizer data from this morning (April 1) on 40K participants, 6 months data, works against variants as well, 100% protection severe disease. No joke, these vaccines really work. Ok, super busy x 2 days but will tweet on weekend (vax after COVID-19?) & if huge news before

Good news on real-world data on Moderna vaccine at 6 months (more details later today): >90% effectiveness against all symptomatic COVID; > 95% against severe COVID. Efficacy: how works in clinical trials; effectiveness: how works in real world
reuters.com/article/us-hea…

Another study on real-world effectiveness, this time among healthcare workers in Mayo Clinic system (Florida, Minnesota, Arizona). Very large study & these studies compare groups likely taking same "risks": unvaccinated cohort 23,931; 2-dose vax 44,011
academic.oup.com/cid/advance-ar…

876 symptomatic infections in unvaccinated (37 out of 1000); 22 symptomatic infections in fully vaccinated (0.4/1000). 96.8% effectiveness for Pfizer vaccine; 98.6% effectiveness for Moderna in this real-world large study. Higher than clinical trials.

Another article here on real world effectiveness on vaccines, this time among those >65 in US. Examined respiratory illness admissions among adults >65 from Jan 1, 2021–Mar 26, 2021 in 24 hospitals across 14 states as vaccines first given in this group
cdc.gov/mmwr/volumes/7…

January-March 2021 still high circulating virus in U.S., most vulnerable group for severe illness (>65) &hospitalizations for COVID-19 down 94% with vaccines (Remember, Moderna had few outcomes in their clinical trial among >65 so real-world reassuring on Moderna)

Another stunning study on the real-world effectiveness of the vaccines detailing the vaccine roll-out in Israel even with 95.4% of strains being B.1.1.7 during later phase of roll-out (this paper details findings from Jan 24-April 3 roll-out) thelancet.com/journals/lance…

Pfizer vaccine 95% effective overall against symptomatic COVID-19; 92% effective in preventing asymptomatic infection; 98% effective against hospitalizations, 97% effective against death across all age groups even >=85 yrs. Cases still declining despite full opening March 2, 2021

This high level of effectiveness seen across all age groups even those >= 85 years. Also, even though children not vaccinated (can only use vaccine >16 years old), cases in all age groups massively low even with opening of society. Fastest vax campaign on planet.

And though I had this study on "why not to worry about variants" thread, realized important to add here which is Qatar mass vaccination campaign from Dec 21 2020-March 31, 2021. Although virtually all circulating virus in country at end of that period was
nejm.org/doi/full/10.10…

either B.1.351 (South Africa variant) or B.1.1.7 (UK variant), the effectiveness of the vaccine (Pfizer) remained extremely high for severe outcomes at 97.4%. So must really add here that the effectiveness of the vaccines in real-world settings is

even higher than the efficacy of the vaccines in clinical trials so we should not longer be saying "you have a 5% chance of catching the virus" if you have had the vaccine. These studies show real-world effectiveness even higher & of course your chance of being

exposed depends on circulating cases in your community ( going down in US). Data from 4/26-out of <95 million fully vaxed in US, 6025 symptomatic breakthroughs (0.006%); 0.0006% hospitalizations for COVID; Deaths 0.0001% for COVID (1 in million); cdc.gov/vaccines/covid…