Thread by @tbuytaer

The more people in society are vaccinated, the more of the deaths will be among vaccinated people.

Imagine a scenario where 95% is vaccinated, with a vaccine that is 90% effective, in a target group where IFR is 10% (80+).

(In reality vaccines are a lot more effective)

In that scenario the total number of deaths among vaccinated people will be 2x higher, but their individual chance is 10x lower than that of people who are unvaccinated.

So that might sound like the vaccines are not working.

That the total number is higher among the vaccinated is thus normal, and a result of the fact that there are simply more vaccinated people around. 🤷

If there are more red cars driving around on the roads, more red cars will crash.

You can see the actual (individual) protection provided by the vaccine on the right side, which shows the odds of dying* for vaccinated and non-vaccinated groups.

* For this fictional scenario of only 90% protection. In reality protection is a lot higher.

The vaccines do not offer 100% protection against heavy illness or death (although it is very close) .

So sometimes a (small!) part of the vaccinated people will still end up in hospital.
It's much less likely than if you are not vaccinated, but sometimes still possible.

In my infographic you see two views of the same situation: absolute numbers and odds.

left box:
- 10 unvaccinated, of which 1 died
- 190 vaccinated, of which 2 died

right box:
- 1 out of 100 vaccinated people died
- 10 out of 100 unvaccinated people died

The left box corresponds to "the numbers" that you will see in the news and on dashboards published by CDC, Worldometer, RIVM,...

But the right box is the one that counts.
That one indicates that the vaccines do make a big difference.

So if you might hear about vaccinated people still ending up in hospital, keep this in mind.

This is an example of the 'Base Rate Fallacy':

en.wikipedia.org/wiki/Base_rate…

If someone is throwing percentages at you, a good reflex is to ask yourself: "exactly WHAT is this a percentage of?"

Or you could draw an example: "If I have 100 people in this group and 100 in the other, what happens to those percentages then?" 🤔

Reality is, of course, more complex than just one aspect.

In addition to what I mentioned in the Twitter thread above, there are other aspects to keep in mind when comparing numbers.

Such as, for example, whether the risk is the same in both groups. (e.g. age difference)

The numbers I used in my infographic are fictitional, just to illustrate this concept.

Actual protection of vaccines against death (also with the variants) is more than 90%. (maybe even close to 99.9%)

But I didn't want to draw 10,000 people on my infographic 🤷

See for example this study in the United States, which found that the Moderna vaccine offered between 91.0% and 99.8% protection against death after double vaccination.

medrxiv.org/content/10.110…

Or this study from Qatar where among 265,410 doubly vaccinated, 1616 people were infected, of which 2 died.

2 out of 1616 ➡️ 99.88% protection

nejm.org/doi/10.1056/NE…

I looked at the UK report people are talking about, and the number of vaccinated.

Unless I made a mistake in my calculations, the protection offered by vaccines against death from Delta variant in the UK seems to be:

For people over 50:
- 87.47% for 1 dose
- 98.41% for 2 doses

To calculate this I used three files (links below) to know:
- Vaccination data per age bracket (in %)
- Population per age bracket in UK
- The UK report with cases & deaths, table 4 (page 13-14)

Vaccination per age bracket was in %, I multiplied that with population in that age bracket to get
- number of people > 50 vaccinated 1x: 1 090 119
- number of people > 50 vaccinated 2x: 23 818 668
- number of people > 50 unvaccinated: 288 281

I then divided the deaths > 50 by those numbers:
- deaths > 50 vaccinated 1x: 18 / 1 090 119 = 0.00165%
- deaths > 50 vaccinated 2x: 50 / 23 818 668 = 0.00021%
- deaths > 50 unvaccinated: 38 / 288 281 = 0.01318%

Take the ratio of those percentages to see difference in odds:

0.01318% / 0.00021% = 62,79

So, for people in the > 50 age group, the odds of dying if you are doubly vaccinated are 63x lower than without vaccine:

Or 100% - 1/63 = 98,41% protection

The three sources used for this calculation:

Percent vaccinated per age bracket:
ons.gov.uk/peoplepopulati…

Population of UK per age bracket:
ons.gov.uk/peoplepopulati…

UK report (Table 4, page 13-14) on variants:
assets.publishing.service.gov.uk/government/upl…

PS: Sorry, I just noticed I made a small mistake: I used the percentages of England only, not of all of the UK.

But if the percentage vaccinated > 50 is similar for England, Wales, Northern-Ireland and Scotland, the results will only be slightly different, and same conclusion.

This is the notorious Table 4 in the UK report that people are talking about...
They are claiming that this table proves that the vaccines offer no protection or are even worse than not vaccinating.

But as you see above, that's not actually the case.

As I mentioned above, I made a mistake in the above calculations, but didn't expect it to make a huge difference, since percentages for England and UK are similar enough.

I redid the calculations, and the results and conclusions are indeed similar.

Protection from death for people over 50 who have been vaccinated twice: 98,3%.
Protection from infection with Delta for same group: 95,3%

Or put another way:
20x less likely to be come infected
59x less likely to die from Delta

(Compared to unvaccinated people of same age.)

The gray table from the UK report says it is counting from 1 February.

But that table is only about Delta cases, which were non-existent or negligible before May.

So: "Delta cases/deaths after 1 February" is almost the same as "Delta cases/deaths after 1 May" (or even > 15 May)