Thread by @zexpe

The #CovidUnknowns Vaccination in Children webinar is now on YouTube, so it's time to link up my live-tweets to video presentations.

Starting with @ParsnipsParsons on the rights of the child.

Followed by @russellviner on the keys issues in childhood vaccination for Covid-19.

"60-70% of children have asymptomatic SARS-CoV-2 infection."

"Delta appears to be more severe in adults, but if anything it seems less severe in children."

Covid-19 & Children by @ShamezLadhani

Part 1 - Infection:
"Seroprevalence studies in children show them being infected as much as adults, but more asymptomatic, producing higher levels of antibodies than adults that persist for longer."

Part 2 - Transmission & Educational Settings:

Emma Duncan on post-covid conditions in children.

Even children who have not been infected have had poorer health-related Quality of Life outcomes from the pandemic.

Pros & Cons of childhood Covid-19 vaccination by @adamhfinn

"You can't do something without not doing something else."

High reactogenicity means disruption from children feeling unwell that could impact the flu, HPV and other vaccination programmes.

Valtyr Stefansson shared Iceland's successful teenage vaccination programme, with high turnouts and low negative consequences.

Vaccination unknowns by @StabellBenn.

Natural immunity is stronger and more long lasting. Some vaccines have non-specific effects that may reduce or even increase the risk of other infections. These are unknown at present for the new Covid-19 vaccines.

Vaccine nationalism and the dynamics and control of SARS-CoV-2 by @thecewagnerlab and @chadisaadroy

Modelling shows we can make a much bigger impact on the pandemic through rapid & equitable global vaccine distribution to protect those at risk.

Rustom Antia:

HCoV primary infections are most common in children, boosting adult immunity with secondary infections.

What if primary HCoV infections, e.g. OC43, occurred in adults?

Epidemic in adults lasts 3 years, then becomes endemic in under 10s.

Peter Doshi concluded with the issue of the data that we can't see. Reports that are not published, and even side-effects that go unreported or take a long time to be published.