Michael Mina Profile picture
Physician-Scientist, MD,PhD. Immunology, Epidemiology, Infectious disease, CSO, CMO. Past: Harvard Faculty. BlueSky @michaelmina.bsky.social

Sep 11, 2021, 5 tweets

Notes on sensitivity of rapid Ag tests for what matters: detecting infectious ppl

Sensitivity:

- Highly infectious (ie superspreader levels): >99%

- Moderately infectious (ie infect 2 or 3 ppl in a classroom): 90-95%

- Mildly infectious (ie spread to spouse only) ~80-90%

1/

This Graph of viral load over time helps to explain this sensitivity issue:

Further, symptoms vs no symptoms has no impact on test performance. Studies that say it does are not recognizing the sampling bias that enters their studies.

3/

And here is critical data demonstrating sensitivity in multiple rapid tests to detect infectious virus

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