1/11 LDL-C is not the main cause of atherosclerosis！ We all know that endocrine disorders will produce endocrine diseases, metabolic diseases, cardiovascular diseases, and even tumors! Many hormones in our body are steroid hormones. Many of these hormones come from cholesterol.
2/11 Why “demonize” a basic nutrient in the human body? What is the differences of cholesterol in aorta, coronary artery, carotid artery, middle cerebral artery, arteriole and vein? And why is the incidence in these blood vessels so different?
3/11 Why atherosclerosis is much more severe in the muscular arteries than that of aorta and smaller arteries? Not obvious in the veins? Is cholesterol the main cause? There is basically no concentration difference of various components in the blood in these continuous pipes!
4/11 One said: “Do you drink too much water, which leads to physical obstacles? Can you say that water is toxic? The so-called “model” of mice with high-fat diet is completely different from human atherosclerosis in pathology.
5/11 Granulation tissue repair induced by vascular media injury / dysfunction is the main mechanism of human atherosclerosis.This new theory subverts the traditional atherosclerosis hypotheses and can perfectly explain the characteristics of human atherosclerosis.
6/11 Traditional hypotheses prefer schematic diagrams, lack human pathological evidences, and cannot explain clinical practice. 10 References as follows:
7/11 1. Haemodynamics of atherosclerosis: a matter of higher hydrostatic pressure or lower shear stress? Cardiovasc Res 2021;117(4):e57-e59.
doi.org/10.1093/cvr/cv…
2.Myofibroblast Forms Atherosclerotic Plaques. bioRxiv 2020:2020.07.20.212027.
biorxiv.org/content/10.110…
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3.Medial Injury/Dysfunction Induced Granulation Tissue Repair is the Pathogenesis of Atherosclerosis. arXiv 2020:2010.06683.
arxiv.org/abs/2010.06683
4.Atherosclerotic Plaque Healing. New England Journal of Medicine 2021;384(3):293-293.
nejm.org/doi/10.1056/NE…
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5.Spontaneous Coronary-Artery Dissection. NEJM 2021;384(11):1077-1077.
nejm.org/doi/10.1056/NE…
6.Hypertension Aggravates Atherosclerosis: A Matter of Pressure Remodeling of Myofibroblasts or LDL Accumulation? JACC 2021;77(20):2619-2620.
doi.org/10.1016/j.jacc…
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7.
Promising Etiological Treatments of Artery Diseases
dx.doi.org/10.13140/RG.2.…
8.
Macrophages Transform into Foam Cells by Phagocytosing Tissues Formed by Myofibroblasts
dx.doi.org/10.13140/RG.2.…
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9.
Steroid Hormones Affect Vascular Diseases through Myofibroblasts
dx.doi.org/10.13140/RG.2.…
10.
Atherosclerosis
dx.doi.org/10.13140/RG.2.…
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