1/ Some interesting slides from today's @CDCgov ACIP meeting:
cdc.gov/vaccines/acip/…
Waning immunity?
Or the Delta factor (more infectious, somewhat more immune-evading)?
Some of both.
But in 65+, it's the Delta factor.
2/ Also, those 65+ have a weaker immune response up front.
I'd expect to see the same among immunocompromised persons.
Immunosenescence is a form of immunocompromise.
3/ Why is there ⬇️VE vs hospitalization over time among those among 18-44 yo with 1+ non-immunocompromising chronic conditions?
Confounding by behavior?
If real, this would justify different eligibility criteria by race based on "weathering" argument:
washingtonpost.com/opinions/black…
4/ This (and Israeli data) might justify lowering age of booster eligibility:
5/ Important point:
6/ Almost 11M (~3%) of Americans have already gotten additional doses of COVID vaccine.
7/ I don't think this will surprise anyone:
8/ Exposure & healthcare access certainly do vary by SES, race/ethnicity, and other demographics.
We do not know if "weathering" leads to more severe breakthrough infections by race/ethnicity.
On that, see earlier in this thread:
9/ Many of us have thought that J&J was a two-dose vaccine for some time now:
nytimes.com/2021/08/09/opi…
That more vulnerable populations have gotten more J&J makes giving a 2nd dose to J&J recipients more pressing from an equity perspective.
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