Cassava Sciences is a shambolic scientific charade.
We have assessed virtually every aspect of Cassava's programs, & reveal a pattern of deliberate, coordinated misconduct.
Our letter to FDA & slides:
cassavafraud.com
$SAVA
@DRnotaDR @jesse_brodkin @PatricioMarceso
The scientific and clinical research problems at $SAVA have not been fully appreciated by those who have been convinced that the clinical claims made by the company are meaningful.
$SAVA
$SAVA
$SAVA
$SAVA
cassavafraud.com
$SAVA
cassavafraud.com
After failing for years to develop a me-too opioid drug $SAVA pivots and claims to have a cure for Alzheimers. After first reporting a total failure, $SAVA "re-do" their biomarker analysis and claim miraculous results..
cassavafraud.com
Cassava's clinical claims are too good to be true.. just like their preclinical fabrications
cassavafraud.com
$SAVA
The Simufilam story is based on absurd scientific claims that no other labs have replicated or follow up, and papers with clear evidence of data manipulation..
cassavafraud.com
$SAVA
The crazy $SAVA "Science" ... and worthless patents based Dr. Wang's faked data.
@TheIpHawk
cassavafraud.com
ALL of Cassava's science relies on Dr. Hoau-Yan "Photoshop" Wang ... who has dozens of papers with clear, undeniable evidence of image manipulation. IT IS ALL MADE UP.
$SAVA
cassavafraud.com
There is no real debate that Dr. Wang has been fabricating his research. The CP was spot on, and since then, DOZENS more examples have been identified on PubPeer, including his work with other groups. Wang is a serial fabulist. @MicrobiomDigest
cassavafraud.com
$SAVA
But Wang can't make up ALL the clinical data.. so $SAVA had to find UNRELIABLE clinical investigators to run their trials.. $SAVA picked a doctor with the rare distinction of having received an FDA Warning Letter.
cassavafraud.com
Cassava claims that Simufilam is safe. But can their poorly designed, unreliable trials run by questionable actors be trusted to assess and report safety accurately? Neither we nor the FDA can really know.
$SAVA
cassavafraud.com
@ginakolata @adamfeuerstein @matthewherper @JohnCarreyrou @KatherineEban @Laurie_Garrett @lindsaygellman @AubreyNPR @antonioregalado
@stephaniemlee @KristinaMFiore @MelodyPetersen @kweintraub @ForsythJenn @joewalkerWSJ @aeis17 @stefaniei @cpiller @By_CJewett @DonnaYoungDC
@ginakolata @adamfeuerstein @matthewherper @JohnCarreyrou @KatherineEban @Laurie_Garrett @lindsaygellman @AubreyNPR @antonioregalado @stephaniemlee @KristinaMFiore @MelodyPetersen @kweintraub @ForsythJenn @joewalkerWSJ @aeis17 @stefaniei @cpiller @By_CJewett @DonnaYoungDC @JeanneLenzer1 @CarlaKJohnson @JoanneKenen @AlecGaffney
@BJSahakian we would be interested in your thoughts on this
$SAVA
@DRnotaDR @jesse_brodkin @PatricioMarceso @jsherkow @HollyLynchez @SteveJoffe @MichelleNMeyer @pzettler @GovindPersad @jack_lietzan
Nothing about $SAVA has changed since yesterday.. so I'm going to finish tweeting out the deck from cassavafraud.com ICYMI..
on to the nonsensical clinical data
$SAVA relies completely on Dr. Wang..
and Dr. Wang's biomarkers are as crazy as all the preclinical data
$SAVA makes unrealistic claims across every stage of its development program.. documented in detail in our letter to FDA on cassavafraud.com
It was never just about a single paper, but a clear pattern of behavior.
$SAVA
cassavafraud.com
$SAVA has never tried to properly address the many questions that have been raised.
cassavafraud.com
The grand $SAVA claim, of course, is that Simufilam improves cognition. But no reliable evidence of that exists.
$SAVA employ many tricks to make data look the way they want it to.. and when questioned, have become less transparent
$SAVA cherrypicking
.. and cutting their planned 3 month trial short to only one month
$SAVA key questions that FDA should be asking about the cognitive data
$SAVA
With SavaDx, $SAVA crosses into Theranos territory of fake diagnostics.. and this "trade secret" assay has been revealed to be a western blot comparing 90kDa and full-size 280kDa fragments of FLNA in PLASMA
It makes no sense to be measuring a protein ratio from a single band on a western, yet this is the data that $SAVA presents for SavaDx
Our theory of why $SAVA took the actions that it did..
The FDA NEEDS TO ACT and conduct a FULL INVESTIGATION. The well documented concerns that have been raised span all of the preclinical and clinical results from $SAVA
Nothing has changed despite the continued manipulation of perceptions by $SAVA
We are confident in our analysis, and believe that full investigations will find significant evidence of misconduct across the Simufilam program, with dire consequences.
cassavafraud.com
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