Oral Therapy for Bacteremia and Endocarditis
@IDwithNWD giving talk for @BradSpellberg
"No, you're not in the wrong room, and @BradSpellberg did not get younger and more handsome."
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Historical lesson first.
Where did the myth that we need IV for IE come from?
Have to go back a ways.
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The dooming quote.
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Oral antibiotic blood levels.
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Reality check - no data that IV is better, and it's riskier.
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Score card of trials. Doesn't look good for IV.
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Here's the data for oral vs IV in osteo.
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And the data for bacteremia.
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And finally, endocarditis.
I cut off the funnel plot on the one, sorry.
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Chutzpah.
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Summary.
Bunch of RCTs for oral, no contrary studies for IV.
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Finally, when to switch.
Fantastic talk from @IDwithNWD, standing in flawlessly for @BradSpellberg.
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