Thread by @joietoyourworld

Mga random clue for MTLE: A thread 🤯 #studytwtph #medtechtwt

Principle of Salmonella Tests

wi[DA]l test - [D]irect [A]gglutination ➡️ Somatic O and Flagellar H antigen
typh[I] - [I]mmunoassays ➡️ Anti-OMP

HLA associated disease:

HLA DR3 - SL3 (SLE)
HLA DR4 - R4 (RA - Rheumatoid Arthritis)

Immunoglobulins:

IgA
- [A]nti-inflammatory Ab
- activates [A]lternative pathway ng complement system
- can act as FIRST line of defense (FIRST sa alphabet ang A)

IgD
- prone to proteolysis ('Di kinaya)
- unusual LONG hinge region (Daks)

IgE
- heat labile "Enet 🔥"
- allergE

𝐒𝐘𝐏𝐇𝐈𝐋𝐈𝐒
Stages:
1) Primary - Hard chancre (mahirap [hard] lang sa una [primary])
*** vs. H. ducreyi - soft chancre, painful (masakit kaya nag-CRY (ducreyi)
2) Se[CON]dary - [CON]dylomata lata
3) Tertiary/Late - Gummas (GUMMAla kaya na-LATE)

𝐒𝐘𝐏𝐇𝐈𝐋𝐈𝐒
FTA-ABS Treponema Strains
1) [RE]iter strain - [RE]move cross reactivity
2) Ni[chol]s strain - nag-CHOLlab w/ T. pallidum (reacts with T. pallidum)

"CD(cold temp and drying) PLayer (pallidum)"

T. pallidum subsp. pallidum - susceptible to [C]OLD TEMP and [D]RYING ('Wag malito na P ay subsp. pertenue, walang L 'yon)

𝐖𝐄𝐒𝐓𝐄𝐑𝐍 𝐁𝐋𝐎𝐓

SNOW DROP
[S]outhern Blot - [D]NA
[N]orthern Blot - [R]NA
[W]estern Blot - [P]rotein

# of bands para ma-consider na POSITIVE
5 out of 10 bands - [Lyme] disease (LIMA)
2 out of 3 bands - HI[V] (V ay parang ✌️- 2)

Serological Tests (what is being detected)
1) CANDIdiasis - MANNan and Anti-Mannan = CANDY MAN
2) AsperGillosis - [G]alactomannan
3) HistoPlasMosis - H and M antibodies (Precipitation)

ToRCHeS - Congenital Infections
T - Toxoplasmosis
R - Rubella
C - CMV: Cytomegalovirus (CoMmon Virus - most common congenital viral infection)
H - HIV, HSV
S - Syphilis

📍Fetal Hemoglobins

✨Gower 1 (Epsilon Zeta) = EZ (easy) pa lang kasi una eh
✨Gower 2 (Alpha Epsilon) = TAE (Two, Alpha Epsilon)
✨Portland (Zeta Gamma) = Zige (Zeta) G!/Gala (Gamma) sa PORTLAND

📍TSI
[SL]ant - Sucrose and Lactose
Butt - GLUcose (Glutes)

📍 Phenylalanine Deaminase Test

𝐏𝐞𝐏𝐞 𝐌𝐨 𝐧𝐞𝐞𝐝 𝐧𝐠 𝐏𝐀𝐃. 𝐄𝐰𝐰 𝐕𝐔𝐋𝐆𝐀𝐑 𝐧𝐚𝐦𝐚𝐧, 𝐆𝐑𝐄𝐄𝐍 𝐣𝐨𝐤𝐞
- (P)roteus, (P)rovidencia, (M)organella - PAD (+)
- (E). coli and P. (VULGAR)is - Control
- (+) result is GREEN color
😭😭

📍Wiskott-Aldrich Syndome

✨"Comb the Whiskers" = WISkott-Aldrich is a COMBined T and B cell deficiency
✨"wisCUTE" = small platelets

📍 Rheumatoid Arthritis
✨ "RAYUMA kasi (M)a(C)ipa(G)" = RHEUMAtoid factor is an Ig(M) directed to the F(c) region of Ig(G)
✨ HLA-DR4 - R4

📍 Autoimmune Disorders
✨ gRave's disease (hyperthyroidism - GRAVE) - anti-TSH (r)eceptor VS hashiMOto's disease (hypOthyroidism) - anti-(m)icrosomal
✨PARINcious anemia (Pernicious anemia) - anti-(PAR)ietal cell & anti-(IN)trinsic factor

(1/2)

✨Primary BILIARy Cirrhosis - Anti-Mitochondrial Ab = "AMA na nag-bBILLIARDs"

(2/2)

📍 Reagent Color (BB)
Anti-A = Blue (Asul)
Anti-B = Yellow (Banana)
Anti-D = Colorless ('Di kita)
Anti-AB = Colorless
AHG reagent = Green (ahGREEN)

📍 ABO Discrepancies
Group 1 - weakly reacting or missing antiBodies
Group 2 - weakly reacting or missing antiGens
(una ang B sa G kaya siya yung group 1)
Group 3 - ProTHREEn (Protein) and plasma abnormalities
Group 4 - Miscellaneous problems

📍 ISBT 031-036
031 FORnando Poe - FORS
032 JR - JR
033 LANg - LAN
034 Vida sa - Vel
035 Movie this - MIRL/CD59
036 AUGUST - Augustine

📍 Additional Tumor Markers for Breast Cancer

📍 Polio vaccine
"Salk-salk (saksak) = Salk vaccine (Intramuscular)
"Sabi" = SABIn vaccine (Orally)

📍 MNSs Blood Group
✨MN antigen
- M(A)N- found on Glycophorin A
- (M)ahi(N)a = EASILY destroyed by enzymes

✨ Ss antigen
- (B)ull Shit = found on Glycophorin B
- (SM) (st)ore = S has Methionine, s has threonine
- (S)trong = less easily degraded by enzyme

(1/2)

📍 MNSs Blood Group
✨ Anti-M
- (M)aasim & (M)atamis = reacts best at pH 6.5 and glucose solution

✨ Anti-S/Anti-s
- (G)GSs = IgG; (s)evere HTR, HDN, Hemoglobinuria

✨ Mᴷ phenotype = (K)ulang sa MNS

(2/2)

📍 Kell Blood Group System (ISBT 006)

✨Kell Antigen
-"𝐊𝐢𝐥𝐥 𝐦𝐲 𝐞(𝐗) 𝐧𝐚 𝐬𝐢 (𝐆𝐄𝐑𝐁𝐈𝐂𝐇), (𝐋𝐞𝐜𝐡𝐞)" = Kell is dependent sa Xk protein; ⬇️Kell Ag seen in GERBICH and LEACH type

✨ K₀ phenotype
- "𝐊₀𝐊₀ 𝐍𝐔𝐭" = K₀ is the NUll phenotype

📍 Associated Poikilocytes
✨ 𝐖𝐚𝐥𝐚 (RH null), 𝐧𝐠𝐚-𝐧𝐠𝐚 (mouth-like; stomatocytosis)
✨ 𝐌𝐜Leod phenotype = (ac)anthocytes
✨ dieg𝐎 = spherocytes (bilog); southeast asian OVALocytosis

📍 RBC Mass Recovery
✨ Post-transfusion = 75% (𝟕𝟓 𝐬𝐜𝐨𝐫𝐞 𝐬𝐚 𝐏𝐎𝐒𝐓 𝐭𝐞𝐬𝐭)
✨ degly𝐙𝐄𝐑𝐎lized = 8𝟎%
✨𝐋eukoreduced/Leukopoor = 8𝟓% (𝐋𝐢𝐦𝐚)

📍 Screened infectious markers for blood donation
✨ "𝐇𝐈, 𝐁u𝐒𝐘 𝐂a?" - 𝐇𝐈V 1/2, Hepa 𝐁, 𝐒𝐲philis, Hepa 𝐂