A “shake and bake reaction” is a response to the administration of which of these drugs?
Flucytosine
Ketoconazole
Amphotericin B
Caspofungin
An infusion-related reaction known as “shake and bake” can occur shortly after administration of amphotericin B; a potent antifungal agent.
“Shake” refers to shivers and “bake” refers to fever.
Amphotericin B leads to an increase in PGE₂.
This is likely the mechanism of chills and fever.
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