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The enemy is anybody who's going to get you killed, no matter which side he is on. - Joseph Heller, Catch-22

Mar 15, 2023, 5 tweets

@NarfGb
1/2 SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties
ncbi.nlm.nih.gov/pmc/articles/P…

2/2 Nothing to see here...

Intracerebral HIV glycoprotein (gp120) enhances tumor metastasis via centrally released interleukin-1
sciencedirect.com/science/articl…

Bonus points if you remember this about IL-1:

IL-1 family cytokines and receptors in IgG4-related disease
pubmed.ncbi.nlm.nih.gov/28823915/

@NarfGb do melanocytes respond to gp120 as microglia do?

This was how I found the link with your paper and gp120:

Synthesis of interleukin-1 alpha and beta by normal human melanocytes
pubmed.ncbi.nlm.nih.gov/8176258/

And so, endothelial exposure to homologous gp120 would be a particularly bad idea.
#atherosclerosis

HIV gp120 induces endothelial dysfunction in tumour necrosis factor-α-activated porcine and human endothelial cells
academic.oup.com/cardiovascres/…

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