A tour de force review in @RPTHjournal of NETosis and its contribution to immunothrombosis. Neutrophils cast out NETs to catch bugs (including SARS-CoV-2) but they are highly proinflammatory and thrombogenic. #TeamClots
The original form of NETosis described by the Brinkmann & Zychlinsky labs was when neutrophils “dump their guts”, committing suicide by spilling out their nucleus, forming a fishnet-like structure. Read the @RPTHjournal review for updates on non-suicidal NETosis.… twitter.com/i/web/status/1…
A previous review from Denisa Wagner, with a strong emphasis on the role of NETosis, “Thromboinflammation: From Atherosclerosis to COVID-19”. ahajournals.org/doi/10.1161/AT…
Think about neutrophils as akin to Roman retiarius gladiators who, as a final suicidal act, eject their DNA guts in the form of a fishnet like Neutrophil Extracellular Trap to defeat their microbial adversaries. But NETs have the downside of attracting inflammation and clots.
It is hoped that by knocking out NETosis (eg with PAD4 inhibitors), we may be able to reduce the thromboinflammation that NETs attract. Slide from a talk @ISTH Berlin, 2017. Note that COVID microclots are always P-selectin positive. #TeamClots
Found a photo of myself at the conference centre of the 2017 Berlin @ISTH meeting. It seems like another world—back when arcane knowledge of immunothrombosis wasn't a matter of life and death. The past is a different country. #TeamClots 🥹
Share this Scrolly Tale with your friends.
A Scrolly Tale is a new way to read Twitter threads with a more visually immersive experience.
Discover more beautiful Scrolly Tales like this.