They're coming for our T-cells next.
Adding ORFab1 to the mix. What could possibly go wrong ...
@a_nineties @my2pups2 @Clucky92864053 @Kevin_McKernan @Jikkyleaks @PlanZip @villagerssn @KathMLee1 @janiesaysyay cell.com/cell/fulltext/…
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ORF1ab > NSP1
Let's analyse this gem here ...
we maintain same high b2 related AB levels despite b4.
- this clearly points to immune fixation
- original antigenic sin
"Notably, N and M specific responses were reduced in the group receiving both BNT162b2 and BNT162b4 compared to the group receiving BNT162b4 alone"
- this points to impairment on N,M ABs from B2 version.
- as the b4 contains some M and N protein expression ABs are expected
However, how many humans are left over on this planet willing to take b4 which have not had b2 earlier?
Also, again this points to strong OAS!
If you had S specific b2 = less N or M specific ABs.
If you had S + N+M b4 = dominated response with S + N + M ...
upon your next infection/injection this S+N+M dominated response will take over spreading OAS issues now from S onto other proteins.
visual aid wrt all the ORF and NSP
ht @my2pups2
@GUstaoset @a_nineties @my2pups2 @Clucky92864053 @Kevin_McKernan @Jikkyleaks @PlanZip @villagerssn @KathMLee1 @janiesaysyay however ...
to get stuff to work in the mice, it is likely an overshoot on one end and damages us more than the mice and on the other end may fall flat on its face when confronted with our resistant construction.
I believe most infection is oral/gastrointestinal.
I'd keep it at partially.
Let's have a look at NSP1-4
nsp1:
immune suppression
frontiersin.org/articles/10.33…
and shuts off your own translation nature.com/articles/s4159…
nsp2:
impairs your interferon production = shuts down immune reactions pnas.org/doi/10.1073/pn…
nsp2: impars miRNA suppression leading to to your miRNA going wild @NarfGb biorxiv.org/content/10.110…
nsp3: fun with protease
journals.plos.org/plosone/articl…
nsp4:
aptotic mitochondrial DNA release throughout the body ... fun ...
mdpi.com/2073-4409/11/1…
another simplified ref h/t @my2pups2
2:50 shows the nsp1 being cut free by nsp3 occupying the ribosome
h/t @my2pups2
luckily we have this. where would we be without this #DEI
and remember the Golden Syrian Hamsters?
mdpi.com/1999-4915/15/3…
@Kevin_McKernan @Clucky92864053 @KathMLee1 @PlanZip @GUstaoset @a_nineties @my2pups2 @Jikkyleaks @villagerssn @janiesaysyay I was honestly expecting your contamination research to show also the mRNA to be shoddy due to all the codon optimization, quick hack job and m1Ψ all over it.
Just for the OCD: it is of course ORF1ab, not ORFab1. Noticed the typo just now.
@threadreaderapp unroll please
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