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Sven Dorkenwald Profile picture
Sven Dorkenwald
@sdorkenw
Shanahan Fellow @ Allen Institute and University of Washington. Researcher @ Google Research

Jun 30, 2023, 6 tweets

We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses!

Explore the connectome:

Reconstruction paper: https://t.co/wCI3hASUfD
Annotation paper: https://t.co/3bPTNK9hRk
1/6 https://t.co/dxyZIhSITgcodex.flywire.ai
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…

There are multiple ways to access the data and the number of tools is growing!

Codex: https://t.co/EWcwRiO0Oz

CATMAID spaces: https://t.co/r34MG9oKTM
https://t.co/jXzHz72TOX: https://t.co/T0v3d3cROc
2/6 https://t.co/WXArxqn3G8flywire.ai/apps
codex.flywire.ai
fafb-flywire.catmaid.org
Braincircuits.io
braincircuits.io/app?p=fruitfly…

The main portal to the data is Codex. For every neuron, one can now query its connectivity, size, neurotransmitter, labels, etc. but also analyze network graphs and find pathways between neurons!

CT1 neurons:

Render by @amyneurons

3/6 https://t.co/VdnyIIz8JDcodex.flywire.ai/app/cell_detai…

@amyneurons In our paper, we analyzed the ocellar circuit (image), produced a projectome between all brain regions, and computed information flow from input to output neurons. These barely scratch the surface of what one can now analyze!

all ocellar neurons:

4/6 https://t.co/dI25CKqS3Mflywire.ai/discover/ocell…

@amyneurons FlyWire is an extremely collaborative project. Over 200 community members contributed >100 edits each to correct the automated segmentation! Flywire uses EM data published by @ddavi et al., typed synapses from @janfunkey @gsxej, @herrsaalfeld et al..

5/6 https://t.co/xriA9f06EAflywire.ai/consortium

Super grateful for the collaboration between
@flyconnectome (@gsxej @Cambridge_Uni, @ddavi @uvmvermont), @AllenInstitute
(@fcollman), and @FlyWireNews (@MurthyLab, @SebastianSeung @PrincetonNeuro)
and funding from the @NIH @USBrainAlliance, @IARPAnews and @wellcometrust that… https://t.co/NEd1UpykiOtwitter.com/i/web/status/1…

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