Just another🧵
1/6
What are a few PRRs?
@DoorlessCarp @Maples46014332 @AnneliseBocquet @Fynnderella1 @ScienceThorsten @carl_jurassic @kksheld @kacdnp91 @ARadlerPohlDr @Jikkyleaks
(1) sciencedirect.com/science/articl…
2/
(Won't be bad: Ask the authors. P.s.: As long as we parrot save and effective we can publish.) frontiersin.org/articles/10.33…
3/
Let's 1st look at the LNPs:
(1)
Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size
(2)
(3)
(4) journals.plos.org/plospathogens/…
ncbi.nlm.nih.gov/pmc/articles/P…
cell.com/iscience/fullt…
sciencedirect.com/science/articl…
4/
What does it mean when they really refunctioned pattern recognition receptors? All bad you can immagine!
@Kevin_McKernan I hope you'll find the 2nd quote very interesting, dear Kevin. ncbi.nlm.nih.gov/pmc/articles/P…
5/
The mod-RNA-simulation
Who thinks they did not know: Trust me guys. THEY KNEW!
(3+4) nature.com/articles/nrd42…
cell.com/molecular-ther…
ncbi.nlm.nih.gov/pmc/articles/P…
6/6
And now add all the unknowns to damaged TLR like
epigenetic changes
the plasmids
endosomal escape distances
interactions with miRNA and lncRNA
membrane damage (see also: )
Addendum
Addendum 2:
Oh yeah... A few Anti-PEG-antibodies are 4 free inclusive.
pubs.rsc.org/en/content/art…
Addendum 3
@ARadlerPohlDr @Maples46014332 @Fynnderella1
What could just go wrong with the signaling cascades?
Remember: We're just missing 1343 proteins and with that how many interactions? 🥴
Addendum 4
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_
Knowingly. patentimages.storage.googleapis.com/de/67/95/27ec2…
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ Since 2012! Knowingly!
Crimes against humanity.
@Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg To explain the problem a bit more understandable:
it's the RNA/content (including the DNA) that matters. And since there is no way to quantify the integrity CONTROLLED in a bulk product, the biodistribution is randomized (since it will also affect the size, charge and direction
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg of the LNPs) and so are the accompanying gene alterations. There is only one constant that you can predict with certainty: It will shred the cell membrane and all receptors and trigger profound signaling switches downstream - especially, but not only - regarding inflammatory
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg processes. So you'll alterate a lot of geneexpression like interleukines, p53, PPAR, etc...
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Funfact: It will also depend if you get the 1st or the last dose of a vial cause of the LNP integrity and concentrations
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg
Btw: You shouldn't be surprised about BRCA1/2 problems. ncbi.nlm.nih.gov/pmc/articles/P…
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 7
cell.com/molecular-ther…
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 8
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 9
It sucks to be right the whole time. Told ya: PRRs won't be the only receptors, didn't I?
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 10
Of course I fall back into my love-hate relationship!
(4)
Stay a way from thinking logical! frontiersin.org/articles/10.33…
sciencedirect.com/science/articl…
mdpi.com/2072-6694/13/2…
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @ScienceThorsten @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway
pubmed.ncbi.nlm.nih.gov/34866574/
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg
I love Carl's memes. ♥
cancercommons.org/latest-insight…
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 11
Nice overview of inflammatory responses.
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 12
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 13
That few crosstalks. Immagine I would have mentioned mTOR in detail and RIG-1. How many crosstalks more?
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg And I was so gently not to show how TLR4 for example works in detail with MYD88/TIRAP and TRAM/TRIF to TRAF before even touching MAPk.
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg Addendum 14
That bit penetration of the Phospholipid Bilayer won't be that bad, will it?
(1+2)
(3+4) bmcplantbiol.biomedcentral.com/articles/10.11…
pubmed.ncbi.nlm.nih.gov/26880639/
@Jikkyleaks @DoorlessCarp @SHomburg @Fynnderella1 @TheEyes2022 @richardursomd @Maples46014332 @AnneliseBocquet @andrewbostom @joshg99 @carl_jurassic @BanounHelene @goddeketal @RetsefL @ClareCraigPath @JesslovesMJK @rosenbusch_ @Kevin_McKernan @KLVeritas @kacdnp91 @drakchaurasia @tkp_at @TracyBethHoeg dx.doi.org/10.1073/pnas.2…
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