Viral infections may show striking T-cell atypia; which in the absence of adequate clinical history, may be worked-up for T-cell lymphoma
Below are pictures from a peripheral blood smear of a patient with an acute viral illness & remarkable lymphocytic atypia #hemepath #lymsm
Flow cytometry analysis confirms the nature of these numerous atypical cells by morphology as lymphocytes, with a predominant CD3-positive T-cell population #hemepath #lymsm #PathTwitter #PathX #SoMe #MedTwitter
This T-cell population consists predominantly CD8+large granular lymphocytes #hemepath #lymsm #PathTwitter #PathX #SoMe #MedTwitter
With dimmer CD7 expression #hemepath #lymsm #PathTwitter #PathX #SoMe #MedTwitter
And dimmer CD5 expression #hemepath #lymsm #PathTwitter #PathX #SoMe #MedTwitter
However, this population appears to show a non-clonal pattern of expression of TRBC1 , supportive of the reactive & non-neoplastic nature of the T-lymphocytosis #hemepath #lymsm #PathTwitter #PathX #SoMe #MedTwitter @saada_vsaada
🩸Not every expanded lymphocytic population by flow or atypical population by morphologic examination is neoplastic
🩸Clinical context is key in these scenarios
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