Thread by @DrShayanSen

Alzheimer’s isn’t caused by bad genes.

It’s metabolic damage that slowly shrinks your brain.

It begins 20 years before doctors ever catch it.

Here’s the blueprint to stop memory loss — before it’s too late: 🧵

1. Memory Loss

Alzheimer’s doesn’t start when grandma forgets your name.

It begins 10–20 years earlier: neurons suffocating, the hippocampus shrinking, and brain metabolism collapsing.

By the time symptoms show, half the brain’s fuel system is gone.

2. Why your doctor misses it

Medicine has been obsessed with amyloid plaques for 30 years.

Billions spent, dozens of drugs failed.

But plaques are a symptom, not the cause.

The fire alarm, not the fire.

Meanwhile, metabolic damage keeps burning your brain down.

3. The real root: brain insulin resistance

Neurons run on glucose + ketones.
But when insulin stops working, the brain can’t use all the fuel.

• Neurons starve
• Synapses collapse
• Memory fades

This is why researchers now call Alzheimer’s Type 3 Diabetes.

4. 5 ways it destroys your brain

• Glycation: sugar binding to neurons like rust
• Inflammation: cytokines frying synapses
• Plaques: dead protein clumps, byproducts of chaos
• Shrinkage: hippocampus loses 10–15% volume
• Mitochondria: energy plants go dark

5. The real risk factors (not genetics)

• High fasting insulin (>8 µIU/mL)
• HbA1c above 5.5%
• Belly fat (waist-to-height >0.5)
• Poor sleep + blue light at night
• ApoE4 gene = higher sensitivity

6. How to bulletproof your brain

Forget crossword puzzles, real prevention is metabolic:

• Strength train (muscle = glucose sponge)
• Daily movement (walk after meals)
• Intermittent fasting (boosts ketones, clears plaques)
• Eat protein + healthy fats, cut down refined carbs
• Sleep 7–9 hrs (deep sleep = brain detox)

7. Key supplements for brain defense

• Creatine (fuels mitochondria)
• Omega-3s (DHA = brain insulation)
• Magnesium threonate (crosses Blood Brain Barrier)
• Curcumin (anti-inflammatory)
• Urolithin A (mitochondrial cleanup)

These target the actual drivers of Alzheimer’s.

8. Tests to request now

Don’t wait for memory loss.

Ask your doctor for:

• Fasting insulin (aim 3–5 µIU/mL)
• HbA1c (<5.3%)
• ApoE genotype (know your risk)
• MRI volumetrics if family history
• Omega-3 index

What gets measured gets managed.

FInal Thoughts:

Alzheimer’s isn’t inevitable.
It’s not “bad luck” or “just age.”
It’s metabolic damage over many years.

Fix insulin resistance, protect mitochondria, and it can be prevented.

Bookmark, RT and follow @DrShayanSen for more threads on root causes of disease.