Next the 2 highest scoring abstracts. PNH and aplastic anaemia - Anita Hill and Morag Griffin #BSH2017
Immune hit on marrow in AA tends to spare PIG-A mutated PNH clone, hence allowing expansion #BSH2017
What is the impact of concomitant use of ATG and eculizumab? Increase in infection doesn't appear to be a problem #BSH2017
40-60% patients with AA have a PNH clone #BSH2017
PNH team looked at all patients who had immune suppression and then eculizumab within a year. Age matched controls from AA database #BSH2017
Remission rates appear comparable between those treated for AA alone versus those also on eculizumab #BSH2017
Other outcomes also show no difference and HSCT can be undertaken successfully on eculizumab #BSH2017
Morag reminds us PNH clones should be monitored every 3/12 in AA patients even if no clone apparent at the start #BSH2017
#haemSpRs will know there are great BSH guidelines on AA onlinelibrary.wiley.com/doi/10.1111/j.… #BSH2017
Aplastic anaemia should be treated as per guidelines irrespective of presence of PNH clone (which may also need treating) #BSH2017
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