Austin Kulasekararaj on extending remission beyond transplant in MDS #BSH2017
<5% pts with MDS undergo transplantation
Of those transplanted, 35-40% are cured #BSH2017
Clone will not be eradicated prior to transplant as HMAs do not affect stem cells but presence of clone post BMT predicts relapse #BSH2017
Blast count >5% at time of transplant predicts poor outcome #BSH2017
Pre emptive azacitidine post transplant may enhance GvL without giving excess GvHD through effects on T cells #BSH2017
Lenalidomide has also been used pre emptively post BMT but may increase GvHD risk ?due to dose/timing #BSH2017
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