Dr Suzy Morton 🅾️➕ Profile picture
Clinical haematologist delivering transfusion #blooducation in the West Midlands. Co-founder of @blooducation. Opinions my own. Tweetorials not peer reviewed.

Sep 14, 2017, 13 tweets

Good to be in Glasgow on a sunny Sept morning! Dr Michelle Willecombe on HLA matching for transfusn in solid organ transplant pts #bbts2017

HLA matching of organ is critical for outcomes in renal transplant recipients - due to HLA abs causing rejection #bbts2017

HLA abs that exist prior to the transplant also associated with worse outcomes #bbts2017

Presence of HLA abs associated with worse outcomes even if not correlating with HLA antigens on the transplanted kidney #bbts2017

Transfusion, pregnancy and previous renal transplant responsible for HLA alloimmunisation in this group #bbts2017

Less transfusions in renal transplant recips in the era of epo use #bbts2017

Some data in the 1970s suggested renal transplant outcomes better in those who had been transfused... much has changed since then! #bbts2017

Pts receiving blood from HLA matched donors were less sensitised but >20% receiving unmatched blood became ineligible for renal transplant

Historically thought that HLA ags not expressed on red cells but they are - so leucocyte reduction does not stop HLA sensitisation #bbts2017

Sensitisation following transfusion is more common in women and black patients #bbts2017

Transfusions should be avoided where possible in potential renal transplant recipients #bbts2017

Immune suppression may reduce risk of alloimmunisation but data are conflicting #bbts2017

Studies underway looking at matching blood to transplant recipients... logistics could be interesting #bbts2017

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