Good to be in Glasgow on a sunny Sept morning! Dr Michelle Willecombe on HLA matching for transfusn in solid organ transplant pts #bbts2017
HLA matching of organ is critical for outcomes in renal transplant recipients - due to HLA abs causing rejection #bbts2017
HLA abs that exist prior to the transplant also associated with worse outcomes #bbts2017
Presence of HLA abs associated with worse outcomes even if not correlating with HLA antigens on the transplanted kidney #bbts2017
Transfusion, pregnancy and previous renal transplant responsible for HLA alloimmunisation in this group #bbts2017
Less transfusions in renal transplant recips in the era of epo use #bbts2017
Some data in the 1970s suggested renal transplant outcomes better in those who had been transfused... much has changed since then! #bbts2017
Pts receiving blood from HLA matched donors were less sensitised but >20% receiving unmatched blood became ineligible for renal transplant
Historically thought that HLA ags not expressed on red cells but they are - so leucocyte reduction does not stop HLA sensitisation #bbts2017
Sensitisation following transfusion is more common in women and black patients #bbts2017
Transfusions should be avoided where possible in potential renal transplant recipients #bbts2017
Immune suppression may reduce risk of alloimmunisation but data are conflicting #bbts2017
Studies underway looking at matching blood to transplant recipients... logistics could be interesting #bbts2017
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