, 13 tweets, 7 min read Read on Twitter
Next up is Maxim Daniel Seferovic @MaximSeferovic, Baylor College of Medicine, with "Our earliest microbial encounters and the developmental origins of disease".
#MBCongress2019
@MaximSeferovic Maxim Seferovic: What are the long term consequences of early exposures to microbes? Genomic variation and epigenomics only partially explain diversity of human phenotypes.
#MBCongress2019
@MaximSeferovic Maxim Seferovic: Do microbial metagenomes contribute to our phenotypic diversity? Which factors, including maternal factors, determine microbial exposure early in life?
#MBCongress2019
@MaximSeferovic Maxim Seferovic: The vaginal microbiome is different during pregnancy - diversity is temporarily diminished during pregnancy (Pace, revised submission).
#MBCongress2019
@MaximSeferovic Maxim Seferovic: There is a mismatch of microbial taxa between the gut of newborns (first days of life) and vaginal bacteria. Are babies exposed to bacteria before birth?
#MBCongress2019
@MaximSeferovic Maxim Seferovic: The uterus (womb) is not sterile; it is open to the vagina. There might be microbial exposure to the developing fetus. Placenta functions as a conduit for microbial communication between mother and fetus.
#MBCongress2019
@MaximSeferovic Maxim Seferovic: We did in situ hybridization (amplified FISH) labeling of placental tissue. We found bacteria in roughly half of the placentas in cesarean, term, healthy pregnancies. Not in all tissues, though.
#MBCongress2019
@MaximSeferovic Maxim Seferovic: Meconium is different, while mouth/gut/nose of newborns look very similar. At 6 weeks old, microbiomes of newborns are diversified / differentiated.
#MBCongress2019
@MaximSeferovic Maxim Seferovic: We did not find any effect of cesarean delivery on community. See Chu 2017: nature.com/articles/nm.42…
#MBCongress2019
@MaximSeferovic Maxim Seferovic: Directly after delivery, neonates are seeded with maternal strains. These are gone after 6 weeks.
#MBCongress2019
@MaximSeferovic Maxim Seferovic: We confirmed in animal studies that placental sequences were different than those found in kit reagents. These are not contaminants.
#MBCongress2019
@MaximSeferovic Maxim Seferovic: Animal experiments: maternal high-fat diet alters the offspring gut microbiome from fetal life, onto adult life (in monkeys). Maternal factors (diet, breastfeeding) influence early exposures.
#MBCongress2019
@MaximSeferovic @threadreaderapp unroll for me please
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