, 14 tweets, 5 min read Read on Twitter
I switched to Track 2 but the talk started too early so I missed half of it :-(
Amir Bein - Human intestine chip colonized with complex gut microbiome for in vitro disease modeling and drug testing
#MBCongress2019
Actually, his talk is already finished. I only saw the last 2 slides. That is too bad - I had hoped to see more of it. :-(
#MBCongress2019
OK, all of us from the other rooms complained, and Amir Bein is kind enough to give his talk again - Yay!
#MBCongress2019
Amir Bein: Challenges in drug development: it costs a lot of money to do studies, and animal studies are difficult and not always good models for human disease.
#MBCongress2019
Amir Bein: We built a microfluidic device with a membrane, that mimics a human lung, with different cells and media on different sides of the membrane. We can use this to study e.g. adherence of certain immune cells, and measure this with a microscope.
#MBCongress2019
Amir Bein: shows videos of cells flowing over the chip, or adhering to it.
#MBCongress2019
Amir Bein: We took this technique further to develop "organ on a chip" modules, such as the "gut on a chip". Epithelial cells are seeded on a membrane, and fed with liquid flow. These develop vili-like structures.
#MBCongress2019
Amir Bein: Mechanical cues are important. But we can also co-culture with microbes. We see that bacterial exposure increases the barrier functions. They change the morphology as well: higher villi.
#MBCongress2019
Amir Bein: Inflammatory bowel disease model (Kim 2015, PNAS). We can also study protective effect of probiotic therapy. We can grow anaerobic bacterial communities on these chips too.
#MBCongress2019
Amir Bein: We also developed a primary human small intestine chip, with beautiful villi. Transcriptomic analysis: it really resembles the duodenum much better than older models.
#MBCongress2019
Amir Bein: We use this chip to study Environmental enteric dysfunction: stunted growth because of recurrent infections and poor nutrition.
#MBCongress2019
Amir Bein: Doing all these complex studies would be very hard in most in vitro models, but this chip allows to study and measure many variants.
#MBCongress2019
Amir Bein: It takes about 3-4 weeks to grow the complete organ/chip model. Thanks to the amazing team at the @wyssinstitute and the @gatesfoundation.
#MBCongress2019
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