, 14 tweets, 12 min read Read on Twitter
The second talk of this session will be by Johan van Hylckama Vlieg, @vanHylckama, VP of Microbiome & Human Health Innovation, @Chr_Hansen with "The microbiome as a source of next-generation probiotics and therapeutic microbes"
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: I changed my title to "Microbes Matter - More than Ever". I work for @Chr_Hansen, a company in Denmark, the largest producer of live bacterial cultures - for over 140 years!
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Food cultures and enzymes (mainly dairy cultures), health & nutrition, and therapeutics. We ship trillions of bacteria every day!
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Industrial production of bacterial cultures involves huge fermentors! Everything gets big at this scale. We also know a lot about dosage forms and stability e.g. at room temperature.
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: More than 100y ago, Elie Metchnikoff postulated that supplementation of diet with lactic acid bacteria has health benefits, even if you cannot consume dairy products.
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Lactobacillus rhamnosus LGG was isolated from human gut in 1983, used worldwide for more than 20 years. Tested eg. in preterm infants, pregnant women, elderly. Prevents infections in children, and promising results in other fields.
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: LGG produces pili important for mucus adhesion. However, genomic locus for these pili is absent in some strains - see: aem.asm.org/content/79/7/2…
Luckily, in our production chain, the pili locus is present throughout. :-)
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Given homology of LGG pili to Vancomycin-Resistant Enterococci (VRE) pili, it might be helpful in eradication of VRE infection. aem.asm.org/cgi/pmidlookup…
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: The small intestine is a highly attractive target for probiotic interventions - much lower bacterial density.
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Much interest for the role of gut barrier function in maintaining health - and many in vitro models to study this. We are currently studying the effect of probiotics on aspirin-induced damage (ulcers).
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: New probiotics (other than Lactobacillus and Bifidobacterium spp) are being investigated: Clostridium, Eubacterium, Faecalibacterium, Akkermansia, Christensenella spp.
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: After the hype: more realism and managing expectations.
The Zmora 2019 paper gives an excellent overview on food as a modulator of the human gut microbiome.
nature.com/articles/s4157…
#MBCongress2019
@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Dobzhansky 1973 said: "Nothing in biology makes sense except in the light of evolution"
Let me end by giving you a variant of that statement:
"Nothing in probiotics makes sense except in the light of the microbiome"
#MBCongress2019
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