@FASEBorg mtgs have no photog/no recording rules so I am not going to talk about other ppl’s unpublished data but a few observations /1
John Denu & I organized the first NAD biennial in 2009. We’ve alternated between US & Europe since. We hit high water mark here with twice as many participants as a decade ago /2
Great time to work on NAD—we are uncovering new types of regulation, connections to health, metabolic stress, aging & disease while there is also significant effort to do clinical testing, especially with #nicotinamideriboside /3
There is a need for trusted methods & reagents to crack several unresolved issues. WldS and SARM1 is resolved to my mind. Yes WldS makes NAD and SARM1 degrades NAD but NMN induces SARM1 to form cADPR and that’s sufficient for SARMoptosis /4
Other things less clear at the moment—seems to me that the days of PARP as a bad actor & expectation that SIRTs are always good actors are numbered. More ppl thinking about redox functions of NAD and more ppl thinking about Ca2+ signaling /5
• • •
Missing some Tweet in this thread? You can try to
force a refresh
