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Antonio Regalado Profile picture
@antonioregalado
Jul 17, 2019 • 4 tweets • 2 min read • Read on X
In 1999, Red Herring magazine under @jason_pontin created the greatest April Fool hoax ever, involving a device called the "orrechio" or ear, which using TIDE protocol) Telepathic Internet Data Exchange") allowed users to compose and send e-mail telepathically.
@jason_pontin This item had an incredible kicker. The CEO of the fictional company, Yuri Maldini, falls silent when asked what the market for the device will be.

.... "i just sent you an email with my answer."
hey @jason_pontin do you have a copy of the cover or feature art for that. I do believe it is VERY similar to this Neuralink artists rendering from yesterday.
/end

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More from @antonioregalado

Antonio Regalado Profile picture
Dec 16
Claim: a stem-cell first

This company's IVF technology matures eggs in a culture of iPSC (induced stem cell)-derived ovarian cells.

A baby was born in their trial, marking "first ever human birth using using iPSC technology" company claims.

couple comment in 🧵
Main takeaway. Almost out of blue, this IVF tech could be on track become the first treatment using pluripotent stem cells -- i.e. stem cells with embryonic properties that can make anything.
embryonic stem cells were isolated from human embryos 25 years ago. Amazing cells (can make anything).

But progress agonizingly slow. No products yet! Image
Read 13 tweets
Antonio Regalado Profile picture
Mar 5
Doctors in Germany study man who received 217 (!! 🤪)) Covid-19 vaccinations. Image
He got

1 J&J
5 Astra Zeneca
211 mRNA (Moderna and Biontech)

Here is the chart of his activities from the case report, published in Lancet Infectious diseases Image
Why did he do it? The man was suspected of trying to get vaccine cards for resale. But criminal charges never filed.

Here's a story from 2022 when he was caught. This did not stop him from getting more vaccines, however.
latimes.com/world-nation/s…
Read 10 tweets
Antonio Regalado Profile picture
Aug 23, 2023
Did covid-19 start in Wuhan? Not according to China's patent office.

The intellectual property organization is changing the text of patents on drugs and vaccines to remove references to covid-19's starting place.

Examples follow. 🧵
First, the (im)moral of the story. China alters the facts in technical documents for what are likely political reasons and U.S. corporations go along with it.
Example 1: Pfizer's patent on paxlovid.

The US edition (at left) and the machine translation of the Chinese version (at right). Can you see what is missing?

I highlighted the text that was removed. It was the part that said mentioned the outbreak originated in Wuhan.
Image
Image
Read 16 tweets
Antonio Regalado Profile picture
Jan 27, 2023
Eric Lander will return next month to Broad Institute and faculty positions at MIT and Harvard. He was on two-year leave to serve as White House science adviser, but got booted from that post for bullying.

Todd Golub remains director of Broad.

intranet.broadinstitute.org/news/eric-land…
This seems to settle the succession question at the Broad Institute, which was founded by Lander. Over the years, other contenders, like David Altschuler and Aviv Regev, departed for industry.
Lander is 65, according to Google, nominal retirement age, but that doesnt mean much in academia. According to Broad, Lander will return to research, mentoring and, one expects, institution building activities.
Read 4 tweets
Antonio Regalado Profile picture
Dec 13, 2022
Documentary about the CRISPR babies saga is out.

Features unusual access to recorded calls with Jiankui He, the Chinese scientist involved + who this year got out of prison. Also a unique interview with his American PR rep, Ryan (no surname used).

I am in the movie, too. 1/x
2/ I travelled with this documentary team to China in Oct/Nov 2018 on the *theory* that if there were CRISPR babies, they would be found in China. (this was before the news broke).

Here is the crew filming with Harvard Prof. George Church in China.
3/Incredibly enough, the fates decreed we would encounter JK during the trip, and a couple of weeks later it became clear he had actually made crispr babies. He posted some data about the babies online, leading to our scoop about the project. technologyreview.com/2018/11/25/138…
Read 15 tweets
Antonio Regalado Profile picture
Nov 6, 2022
An "single patient" IND for a CRISPR therapy for muscular dystrophy: the patient died.

What does it mean for genetic therapy? Lack of clear info makes this one tough to analyze...
I looked around but couldn't easily locate either a clear description of the product, code name CRD-TMH-001, nor the dose.
This one-off CRISPR study was organized by Cure Rare Disease, a non profit whose CEO is Rich Horgan.

The deceased patient is his brother, Terry Horgan (who had muscular dystrophy).

He died in the second week of October according to the organization.
cureraredisease.org/blog-posts/upd…
Read 13 tweets

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