, 10 tweets, 3 min read Read on Twitter
This RT is not an endorsement. This are horrible #InMice experiments that do not induce anything that resembles human depression.
Putting mice in wet, no-bedding, or 45 degrees tilted cages, or immobiling them in a 50 ml tube is inducing severe stress, not depression.
Shame on @institutpasteur for approving this.
See my previous statements on this type of research here: retractionwatch.com/2017/02/28/ani… and here: scienceintegritydigest.com/2019/05/24/dep…
I cannot find the Supplemental materials from my phone, but it seems mice received several different stressors each day for a total of 8 weeks.
Just imagine having to live in a room that unexpectedly would tilt for 45 degrees or flood for a couple of hours, for 8 weeks in a row. Yes that is a depressing thought. But very different than human depression.
Here is the "unpredictable chronic mild stress (UCMS)" treatment schedule for you to enjoy.
Imagine a human being treated like this for 8 weeks.
I am not an MD, nor trained in psychiatry, but I would assume that this type of treatment could result in extreme anxiety or PTSD, rather than depression.
So a mouse model like this (although I would still be very uncomfortable with it), might have some merit in exploring neurological pathways or treatment options for PTSD/anxiety, but it seems to not be a good model for human depression.
I posted my concern on bioRxiv. Not sure if it will pass moderation, so I will post it here as well.
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