Thread: History of SSRIs & Other Commonly Prescribed Antidepressants.

How did we get here?

SSRIs (selective serotonin reuptake inhibitors) are the current first line therapy for depressed patients despite a clear lack of public confidence and a lack of consensus from mental health providers.

Please review this quick video before proceeding.
Disclaimer: I'm not giving medical advice or making recommendations.

This is merely my analysis of open source information on this subject.

Please consult your doctor before stopping an SSRI or any other antidepressants.
In the two minute video I want to make sure you caught the key word "hypothesis."

You see, SSRIs are prescribed despite a consensus over the mechanism of action (moa).

There are currently several theories as to how they work to alter mood.…
We have to go back and consider the development of antidepressants before I get too far ahead of myself.

After WW2 there was a sudden serendipitous discovery of the first antidepressant (imipramine) by Swiss researchers beginning the "chemical imbalance" era of psychiatry.
The timing of this discovery should be scrutinized with the knowledge that the OSS/CIA were conducting Project Paperclip during this time.

In fact..

Hitler's chemists were feeding our CIA with drugs developed by the Swiss that had "military potential.…
Of course the drug they were promoting then was LSD. This would lead to the now famous MK (mind control) projects and other covert operations testing the effects of LSD on individuals & large populations.
Throughout the 50s & 60s we see a robust development of antidepressants which became intertwined with emerging developments in psychoanalytic psychiatry.

"Big Pharma" now had neverending demand for drugs prescribed by providers with no real diagnostic tools.
Scientific research was shifted away from more common diseases and government (CIA) grants flooded the community to develop better antidepressants.

Including LSD of course.
The basis of how LSD (along with other drugs) works is increasing neurotransmission in your brain. Much like the 2 minute video at the beginning of this thread.

Specifically serotonin.

LSD may also increase neurogenesis (new brain cells) like SSRIs.
Now to get back to my goal...

So modern studies indicate that patients who are taking SSRIs for at least 3 weeks report minimal or NO effects from LSD.

For patients with only one week of an SSRI they had INCREASED effects.
It just so happens that patients who start an SSRI generally need about the same 2-3 weeks before they "adjust" to their med. The positive effects on mood can take about 3 weeks before noticed.
You may have heard the warnings about suicidal thoughts.

Studies have shown that in the first week of starting an SSRI (or changing dose) patients are at an increased risk for suicidal ideation. This increases in patients who already have these thoughts and people under 24yo.
For the most part this increased risk for suicide is a result of the initial increase in neurotransmitters. Whereby we see increases in serotonin, norepinephrine, dopamine etc.

This is creates a sense of "motivation" & energy for the patient.
Which is awesome for many people who really are "stuck" in their depressive state. Picture them jumping out of bed and following through with daily goals etc.
However, for patients who are struggling with suicidal thoughts this extra "motivation" and ability to follow through can be very dangerous.

What was previously a passing emotionally charged thought now becomes an impulse they are more likely to act on.

"Screw it"
How does this work with the mentally ill shooters that are becoming more common?

Most studies conducted to determine the risk of suicidal thoughts are junk.

They don't address simple confounding factors like compliance/adherence.
Not to mention the aspect that our intelligence agencies have been using illicit chemicals to experiment and carryout operations on our own citizens for half a century.

Should we assume they are advancing their methods in mind control as well? No?
I'm sure DARPA & iARPA will help them out.…
See also:

Project Artichoke…
It is interesting to see the El Paso shooters father is a mental health therapist who works with PTSD patients.…
"Crusius Sr. writes that he has been an addict for almost 40 years despite being a therapist himself saying that he suffered from alcoholism

He said he also took drugs including Vicodine, Quaaludes, hallucinogenics & magic mushrooms"…
I suppose this article would be another to check out..…

This is not a thread meant to stop anyone from taking their medication.

It you have concerns with your meds please contact your doctor.

As I've stated above being noncompliant can be very dangerous.
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