Tonight our clinical article in #EmoryID journal club is being discussed by @Boghuma
#TwitterIDJC
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis | NEJM nejm.org/doi/full/10.10…
#TwitterIDJC
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis | NEJM nejm.org/doi/full/10.10…
Of 204 cases, there were 13 cases where a pathogen was identified by metagenomic sequencing alone, and 7 of those results changed management.
Small yield for applying this technology to such a large sample of patients, especially since metagenomic sequencing alone missed 26 pathogens detected by routine tests.
Likely a helpful technology in the future, but unclear how much additional information it provides right now, especially given the amount of input and discussion needed to interpret these results.
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