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Kevin Mitchell Profile picture
@WiringTheBrain
Aug 22, 2019 • 3 tweets • 2 min read • Read on X
Rethinking the genetic architecture of schizophrenia. - I wrote this with David Porteous in 2011. Apart from an over-emphasis on single rare mutations of large effect (less common for SCZ than for ASD), I think it holds up pretty well ncbi.nlm.nih.gov/pubmed/20380786
Updated in: The genetic architecture of neurodevelopmental disorders biorxiv.org/content/10.110…, from this book: onlinelibrary.wiley.com/doi/book/10.10…
And further updated (in more accessible form) in chapter on The Exceptions, in #INNATE press.princeton.edu/titles/13255.h…

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More from @WiringTheBrain

Kevin Mitchell Profile picture
Jun 26
Really excited to have this new preprint out 😊, with @HenryDPotter: 𝗕𝗲𝘆𝗼𝗻𝗱 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 – 𝗲𝘅𝘁𝗲𝗻𝗱𝗶𝗻𝗴 𝗼𝘂𝗿 𝗰𝗼𝗻𝗰𝗲𝗽𝘁𝘀 𝗼𝗳 𝗰𝗮𝘂𝘀𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 𝗻𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲
osf.io/preprints/psya…
Image
In neuroscience, our search for the causes of behavior is often just = a search for the underlying neural mechanisms. Especially when we can use tools like optogenetics to show some activity is "necessary and sufficient" for that behavior to occur
This relies (sometimes explicitly but more often implicitly) on a 'driving' metaphor - both of neural inputs driving activation and of neural activity driving behavior
Read 8 tweets
Kevin Mitchell Profile picture
Apr 29
Autism: The Truth is (not) Out There - I wrote this ten years ago and it is, depressingly, as relevant as ever...wiringthebrain.com/2014/10/autism…
The evidence that autism has genetic origins is overwhelming. But we don't do a good job of communicating that. And that void is readily filled with pseudoscience... Image
The genetics of autism is genuinely complex - involving both genetic heterogeneity (of rare mutations) and a polygenic background of common variants. pubmed.ncbi.nlm.nih.gov/35654974/
Read 5 tweets
Kevin Mitchell Profile picture
Apr 10
I often get asked where I would draw the line of which kinds of creatures have "agency" or "free will"
I tend to only speak of "free will" in relation to humans, put purely because of the historical baggage that comes with the term. "Agency" I see as co-extensive with life...
Though some creatures have more agency than others, or maybe different kinds that vary along several dimensions. (Like behavioral flexibility, ability to cope with novel situations, time horizons of control, etc)
Read 14 tweets
Kevin Mitchell Profile picture
Dec 6, 2023
A lot of people ask me about my daily routine for neuro-optimising well-being and productivity*

*Narrator: no had in fact asked…

So here goes:
I wake up at stupid o’clock and curse the darkness of the Irish winter. Will I be getting direct sunlight in my eyes this morning? I will in me hole. We won’t see the sun again till February.
I grope my way to the bathroom for a hot shower. Yes, hot. Because it’s 2023 and we’re not fucking cavemen.
Read 12 tweets
Kevin Mitchell Profile picture
Sep 26, 2023
One motivator for arguing against free will seems to be the problem of moral luck and its undermining of moral responsibility. 1/n
The idea being that people's behavior is really determined by past events, including their genetic make-up, upbringing, social circumstances, and accumulated experiences... 2/n
...so how could it be right to blame or punish them for doing acts we call "crimes" when all these antecedent causes were really the determinants of their actions? 3/n
Read 10 tweets
Kevin Mitchell Profile picture
Aug 24, 2023
Thread incoming 🧵 1/13
The concept of “representations” offers a crucial bridge between brain and mind – a way for physical (patterns of neural activity) to manifest as mental; for organisms to be able to *think about things*. 2/13
But representation talk is controversial and laden with baggage. Are they discrete symbolic objects of cognition or distributed states in a dynamic connectionist network? Are they needed at all to explain cognition? How does the meaning of neural patterns get grounded? 3/13
Read 14 tweets

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