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P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Aug 26, 2019 • 3 tweets • 1 min read • Read on X
For $317, you can buy a literal metric ton of sugar. No wonder the food companies love the stuff. isosugar.org/prices.php
Soybean oil futures contract is for 60,000 lbs., and priced in cents per pound.

Current price is 29 cents.

That's very nearly the same price per calorie as sugar.

investing.com/commodities/us…
Butter in lots of 40,000 lbs costs $2.20 a lb, more than 7 times as much as soybean oil.

One reason our food is toxic is because poison is cheap.

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More from @Mangan150

P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jun 25
Cholesterol is so important for brain health that the brain has its own synthetic machinery for making it.

The brain is only 2% of body weight yet contains as much as 25% of the body's cholesterol. Image
Blood levels of total and LDL cholesterol are lower in Parkinson's disease patients.

Ferritin (iron) levels are higher.

[PMID: 21282940]
Some statins, those that are lipophilic, can penetrate the blood brain barrier.

The effects of these statins has been described as "pleiotropic", meaning they do lots of things; since they lower cholesterol, presumably many of these things are not good. https://doi.org/10.1016/j.bbamem.2020.183340
Read 6 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 16
The well-known negative correlation between water hardness and atherosclerotic heart disease can be explained almost entirely by lithium levels. Image
The inverse association of water hardness and cardiovascular disease has been found in many countries. Image
Psychiatric patients taking lithium had massively lower rates of seizures, AML, dementia, and heart attack, compared to psychiatric patients not taking lithium. Image
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 4
How do you know if you're healthy?

Here's my metabolic health scorecard:

1. High blood pressure (without meds)
2. A1C over 5.6% without meds
3. HOMA-IR above 1.4
4. Triglycerides / HDL over 2
5. Overweight or obese BMI
6. High body fat %
7. Waistline > 50% of height Image
High blood pressure without meds:

While there is a genetic component, the root cause of high blood pressure is related to your weight and especially body fat %.
A1C higher than 5.6% without meds:

This one is easy to explain: once you get to an A1C of 5.7% or higher, you get into the pre-diabetic range.

Which is a big red flag.
Read 9 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Feb 26
Why I never workout for more than 75 minutes per week…

And why you should (probably) train even less than I do.

Here's why: Image
What do I mean by working out?

Let's quickly define exercise:

Exercise is planned, structured, repetitive, and intentional movement.

Its role is to improve or maintain physical fitness.

Walking, tennis, swimming or biking leisurely are "activity", not exercise.
Generally speaking, exercise is "programmed" as either"strength" or "cardio".

We'll see why that's nonsense later in this thread.

For now, let's look at why most strength training routines are not the right tool for most. (They're for powerlifters/bodybuilders).
Read 19 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Nov 7, 2023
How does the brain deteriorate in aging, such as in Alzheimer's and in vascular dementia?

Ferroptosis may be a major mechanism of brain white matter injury. onlinelibrary.wiley.com/doi/10.1002/an…
Ferroptosis is a type of programmed cell death which, as its name suggests, is powered (in part) by iron.

The other part of the equation is lipids that contain omega-6 PUFA, namely linoleic acid.

Linoleic acid is the main component of seed (vegetable) oils. Image
Iron reacts with readily oxidized PUFA to form lipid peroxides.

These can be detoxified by glutathione, but if not, leads to ferroptosis and cell death.

Glutathione levels decline with age and can be restored with GlyNAC. Image
Read 8 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Nov 6, 2023
If you wonder why plant polyphenols, such as the compounds in tea, coffee, chocolate, and red wine, are associated with better health, this is why.

They are designed to chelate and block iron. Image
Iron is an underrated factor in aging Image
Human milk is rich in the iron-binding protein lactoferrin, and this is what prevents growth of bacterial pathogens in the infants gut, and allows Lactobacillus to flourish. Image
Read 5 tweets

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