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P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Aug 27, 2019 • 6 tweets • 2 min read • Read on X
A few of you asked me if I could "translate" this thread into simpler terms so that others could better understand. So here goes.
Some arteries are free of atherosclerosis, even when others - in the same person - are loaded with it. Why?

If we can understand that, we can better understand what *really causes atherosclerosis, and hence, coronary artery disease.
The arteries that don't develop atherosclerosis lack "vasa vasorum", which is a separate blood supply to arterial walls.

Yes, some arteries require their own blood supply.

ahajournals.org/doi/full/10.11…
Ischemia - tissue death due to lack of oxygen - of the vasa vasorum leads to atherosclerosis.

This seems to be linked to PVAT - perivascular adipose tissue, the fat tissue that lines arteries.

ncbi.nlm.nih.gov/pubmed/21910690
Insulin resistance can cause dysfunction in this fat, leading to inflammation.

This could explain why insulin resistance leads to atherosclerosis.

ncbi.nlm.nih.gov/pubmed/15910955
There's more, but to summarize, atherosclerosis comes from the outside in, not from the inside.

Insulin resistance, obesity, and aging all lead to inflammation of PVAT, which leads to atherosclerosis.

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More from @Mangan150

P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 16
The well-known negative correlation between water hardness and atherosclerotic heart disease can be explained almost entirely by lithium levels. Image
The inverse association of water hardness and cardiovascular disease has been found in many countries. Image
Psychiatric patients taking lithium had massively lower rates of seizures, AML, dementia, and heart attack, compared to psychiatric patients not taking lithium. Image
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 4
How do you know if you're healthy?

Here's my metabolic health scorecard:

1. High blood pressure (without meds)
2. A1C over 5.6% without meds
3. HOMA-IR above 1.4
4. Triglycerides / HDL over 2
5. Overweight or obese BMI
6. High body fat %
7. Waistline > 50% of height Image
High blood pressure without meds:

While there is a genetic component, the root cause of high blood pressure is related to your weight and especially body fat %.
A1C higher than 5.6% without meds:

This one is easy to explain: once you get to an A1C of 5.7% or higher, you get into the pre-diabetic range.

Which is a big red flag.
Read 9 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Feb 26
Why I never workout for more than 75 minutes per week…

And why you should (probably) train even less than I do.

Here's why: Image
What do I mean by working out?

Let's quickly define exercise:

Exercise is planned, structured, repetitive, and intentional movement.

Its role is to improve or maintain physical fitness.

Walking, tennis, swimming or biking leisurely are "activity", not exercise.
Generally speaking, exercise is "programmed" as either"strength" or "cardio".

We'll see why that's nonsense later in this thread.

For now, let's look at why most strength training routines are not the right tool for most. (They're for powerlifters/bodybuilders).
Read 19 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Sep 21, 2023
Why I never workout for more than 75 minutes per week…

And why you should (probably) train even less than I do.

Here's why: Image
Let's quickly define exercise:

Exercise is planned, structured, repetitive, and intentional movement intended to improve or maintain physical fitness.

Things like walking, swimming or cycling leisurely are "activity", not exercise. Same idea for playing golf or tennis.
Exercise is usually programmed as "strength" or "cardio".

We'll see why that's a mistake later in this thread.

For now, let's establish that most resistance (strength) training routines are designed for powerlifters or bodybuilders.
Read 18 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Aug 30, 2023
Americans taking psychiatric drugs.

Notable: women, people over age 65, and whites. Must be a staggering number of older white women taking one of these drugs.

All of this can't possibly be necessary. Image
jamanetwork.com/journals/jamai…
Many psychiatric drug prescriptions must be driven by the profit motive, together with doctors wanting to treat patients in 10 minutes of office time, and the fact that people think of these as magic pills to cure the blues.
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Aug 23, 2023
One session per week of high intensity exercise reduced risk of heart disease death by 40 to 50%.

There was no additional benefit from increasing frequency or duration of exercise. Image
A single bout of exercise creates clinically relevant protection against cardiovascular events. Image
Literally 2 minutes a week of high-intensity exercise increased VO2max and insulin sensitivity.

2x 20 seconds all-out sprint cycle, 3x a week, not including warm-up or cool down. Image
Read 5 tweets

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