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P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Aug 27, 2019 • 6 tweets • 2 min read • Read on X
A few of you asked me if I could "translate" this thread into simpler terms so that others could better understand. So here goes.
Some arteries are free of atherosclerosis, even when others - in the same person - are loaded with it. Why?

If we can understand that, we can better understand what *really causes atherosclerosis, and hence, coronary artery disease.
The arteries that don't develop atherosclerosis lack "vasa vasorum", which is a separate blood supply to arterial walls.

Yes, some arteries require their own blood supply.

ahajournals.org/doi/full/10.11…
Ischemia - tissue death due to lack of oxygen - of the vasa vasorum leads to atherosclerosis.

This seems to be linked to PVAT - perivascular adipose tissue, the fat tissue that lines arteries.

ncbi.nlm.nih.gov/pubmed/21910690
Insulin resistance can cause dysfunction in this fat, leading to inflammation.

This could explain why insulin resistance leads to atherosclerosis.

ncbi.nlm.nih.gov/pubmed/15910955
There's more, but to summarize, atherosclerosis comes from the outside in, not from the inside.

Insulin resistance, obesity, and aging all lead to inflammation of PVAT, which leads to atherosclerosis.

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More from @Mangan150

P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jun 25
Cholesterol is so important for brain health that the brain has its own synthetic machinery for making it.

The brain is only 2% of body weight yet contains as much as 25% of the body's cholesterol. Image
Blood levels of total and LDL cholesterol are lower in Parkinson's disease patients.

Ferritin (iron) levels are higher.

[PMID: 21282940]
Some statins, those that are lipophilic, can penetrate the blood brain barrier.

The effects of these statins has been described as "pleiotropic", meaning they do lots of things; since they lower cholesterol, presumably many of these things are not good. https://doi.org/10.1016/j.bbamem.2020.183340
Read 6 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 24
Big difference between:

1) Recognizing that most poor food choices contain carbs.

And

2) Claiming that all carbs are “bad”.

I’ve never had a client with a “carb problem” whose carb sources were potatoes, rice or fruit.

The real problem, as I see it, is processed food.
Image
Image
There’s a great lack of nuance on social media.

I am a big proponent of eating animal protein.

And I do think some people thrive on a carnivore or keto diet.

But the idea that everyone should stop eating all carbs forever is deeply flawed...

Undesirable and impractical for most people.

The point is to land on an approach that works for YOU.
As with all things, the devil is in the details.

The appropriate quantity of carbohydrates is going to vary.

Someone on weight loss journey will do better limiting their total carb intake, for example.
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 16
The well-known negative correlation between water hardness and atherosclerotic heart disease can be explained almost entirely by lithium levels. Image
The inverse association of water hardness and cardiovascular disease has been found in many countries. Image
Psychiatric patients taking lithium had massively lower rates of seizures, AML, dementia, and heart attack, compared to psychiatric patients not taking lithium. Image
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 4
How do you know if you're healthy?

Here's my metabolic health scorecard:

1. High blood pressure (without meds)
2. A1C over 5.6% without meds
3. HOMA-IR above 1.4
4. Triglycerides / HDL over 2
5. Overweight or obese BMI
6. High body fat %
7. Waistline > 50% of height Image
High blood pressure without meds:

While there is a genetic component, the root cause of high blood pressure is related to your weight and especially body fat %.
A1C higher than 5.6% without meds:

This one is easy to explain: once you get to an A1C of 5.7% or higher, you get into the pre-diabetic range.

Which is a big red flag.
Read 9 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Feb 26
Why I never workout for more than 75 minutes per week…

And why you should (probably) train even less than I do.

Here's why: Image
What do I mean by working out?

Let's quickly define exercise:

Exercise is planned, structured, repetitive, and intentional movement.

Its role is to improve or maintain physical fitness.

Walking, tennis, swimming or biking leisurely are "activity", not exercise.
Generally speaking, exercise is "programmed" as either"strength" or "cardio".

We'll see why that's nonsense later in this thread.

For now, let's look at why most strength training routines are not the right tool for most. (They're for powerlifters/bodybuilders).
Read 19 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Dec 15, 2023
Here's how I never workout for more than 75 minutes per week…

And why 99% of people should train even less than I do: Image
First things first, why should you listen to me on this topic?

I'm a 68 year old former microbiologist turned health coach who served 1000+ men and women.

Busy people come to me to get lean, fit & 2X energy in 50 mins/week without going keto, counting calories, or doing cardio. Image
I am NOT saying that you should train for 50-75 minutes per week and then sit on your rear end the rest of the time.

We need to distinguish between exercise (training) and activity.
Read 20 tweets

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