Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Aug 27, 2019 • 6 tweets • 2 min read • Read on X
A few of you asked me if I could "translate" this thread into simpler terms so that others could better understand. So here goes.
Some arteries are free of atherosclerosis, even when others - in the same person - are loaded with it. Why?

If we can understand that, we can better understand what *really causes atherosclerosis, and hence, coronary artery disease.
The arteries that don't develop atherosclerosis lack "vasa vasorum", which is a separate blood supply to arterial walls.

Yes, some arteries require their own blood supply.

ahajournals.org/doi/full/10.11…
Ischemia - tissue death due to lack of oxygen - of the vasa vasorum leads to atherosclerosis.

This seems to be linked to PVAT - perivascular adipose tissue, the fat tissue that lines arteries.

ncbi.nlm.nih.gov/pubmed/21910690
Insulin resistance can cause dysfunction in this fat, leading to inflammation.

This could explain why insulin resistance leads to atherosclerosis.

ncbi.nlm.nih.gov/pubmed/15910955
There's more, but to summarize, atherosclerosis comes from the outside in, not from the inside.

Insulin resistance, obesity, and aging all lead to inflammation of PVAT, which leads to atherosclerosis.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with P.D. Mangan Health & Freedom Maximalist 🇺🇸

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Mangan150

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Aug 11
What's the smart way to think about carbs?

Big difference between:

1) Recognizing that almost every crappy food choice contains carb

2) Claiming that all carbs are “bad”.

Let's dive in: Image
Image
I speak from personal experience, and from working 1-on-1 with over 1500 people since 2015.

Here's the truth:

Every single client I've had who said they were "struggling with carbs" was in fact not struggling with any unrefined carb source. Image
Said differently, people who say they have a “carb problem” almost never struggle with things like fruit, potatoes, or even rice.

When you get specific, you realize that it's those processed/junk food sources that are an issue.
Read 9 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 28
The cholesterol hypothesis has been wreaking havoc on human health for 75 years.

This is the idea that higher cholesterol levels, especially LDL, are causally linked to “clogged arteries” and heart disease.

Let’s debunk once again:
Optimal total cholesterol levels are higher in than what current medical dogma states.
Lowering cholesterol is a bad idea if you care about brain health:
Read 8 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 23
The two words that matter most for those who want to improve their health, mood, energy levels and quality of life:

Body composition.

Let’s define it:
Body composition refers to the components that make up your total weight.

There are a few ways to think about the components, the best one in my view being the three-compartment model which includes:

Bone
Fat
Fat-free mass
Fat free mass includes both muscle and organs.

When we talk about getting to and maintaining a low body fat %, it’s generally calculated as:

Fat mass divided by total weight (all three components).
Read 7 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jul 9
The most common reason older men have lower testosterone levels?

It’s not because they’re older.

It’s because they’re fat.
25% of men over 75 have T levels on par with high T young men.

What's stopping all men from having T levels that high?

Carrying excess body fat, and not training correctly.
I think a lot of men (and their doctors) are too quick to jump on the TRT wagon.

Get rid of excess body fat and build a little muscle…

And odds are good you could have naturally high T levels.
Read 4 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jun 17
If you’re going to take away one core idea from reading my posts, it should be this:

Metabolic health = controllable health.
A second core idea is that WHAT you can control by getting in, and staying in good metabolic health is… a lot.

We’re talking about obesity, diabetes, heart disease, fatty liver, visceral fat and many types of cancer.
A third idea:

Your body composition, meaning the relative degree to which you’re lean and muscular, is highly linked to your metabolic health.

If you’re lean (not skinny-fat, overweight or obese) and have some muscle, it’s highly unlikely that you’re in poor metabolic health.
Read 9 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 16
A friend asked ChatGPT what were the most important non-consensus things it has picked up in health, longevity, and healthspan.

First 4 are things I've been talking about a long time.

I'm kinda stunned.

In the follow up, the Chat gave me credit.Image
Image
ChatGPT references

1. Iron as a longevity target

The fine control of body iron stores would be a wise strategy for chemoprevention of several diseases. Image
Glycine and aging: glycine extends lifespan. Image
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(