#Onegoal Q2 of the day... who has the highest priority to receive D neg red cells? (apologies for shorthand!)
...aaand we have a correct answer! Yes, patients who already have alloimmune anti-D are the highest priority to receive D neg red cells. This includes neonates with passive anti-D from mum #blooducation
D neg children and those with unknown blood groups (M and F) should receive D neg blood, but a known D pos child can receive D pos red cells
Women over the age of 60 whose blood group is unknown can also receive D pos blood
R0 (cDe) sickle patients are D pos and should receive D pos (and C neg E neg, K matched) blood, unless blood which meets their (sometimes complex) requirements cannot be met with any other red cells. More on that later in the week!
@NBTC In summary, the order of priority for patients to receive D neg red cells are (in descending order):
1.D neg patient with immune anti-D
2.D neg patients and patients with unknown blood group with child bearing potential...
@NBTC ...3.Children <18 years with unknown blood group in an emergency 4. As a substitution for patients with complex phenotypic requirements e.g. multiple alloantibodies where no other blood is available
@NBTC Here endeth my musings on O D neg for now... watch this space and please do add your thoughts! How are you making sure that #everybagcounts ? Are your transfusion team working towards #Onegoal ?
• • •
Missing some Tweet in this thread? You can try to
force a refresh
I had a personal request to do a tweetorial for the #haemSpRs on haemovigilance. Here goes. A #blooducation 🧵
Haemovigilance is a systematic surveillance of adverse reactions and adverse events related to transfusion’ with the aim of improving transfusion safety. transfusionguidelines.org/transfusion-ha…
We are very lucky in the UK to have @SHOTHV1, one of the first in the world to collate adverse events relating to transfusion - since the 1990s.
This morning I met with the chair and vice chair of the Midlands Regional Transfusion Committee, the Midlands Patient Blood Management Practitioner and the Customer Services Manager. What are their roles and what does the RTC do?
A #blooducation 🧵
RTCs serve to bring together Hospital Transfusion Committees to discuss best practice, implement new guidance and provide educational resources and events. They are run by clinicians and scientists working in hospitals, supported by @NHSBT.
Teaching our incoming haematology doctors today about transfusion in haematology patients. So who needs irradiated blood and why? A #blooducation🧵
All blood in the UK is leucocyte reduced (except granulocytes, but that’s another story). Despite this, a unit of red cells or platelets can have around a million residual white cells, mostly lymphocytes.
Every doctor starting in a new trust does transfusion training as part of their mandatory training. But why?
50ml ABO incompatible blood can kill a patient. ABO antibodies are naturally occurring (“everyone” has them) and they are IgM; they can activate complement and cause *immediate* intravascular haemolysis, causing release of free haem, endothelial activation, renal failure and DIC.
In most hospitals, blood banks require 2 samples (one may be historic) before releasing group specific (non-O) blood for a patient. This is to increase the chances of identifying a *wrong blood in tube* (pt whose blood's in the tube is not the pt whose details are on the outside)
It can be difficult to know where to start with transfusion – you can’t go on a ward round to find patients. BUT you do start with lab induction and your helpful #BMSes will show you around.
Excellent session on emergency paediatric transfusion #AABB20. Cyril Jacquot talking on pre hospital transfusion and summarising the literature.
28 day mortality following haemorrhage is higher in children than adults (unpublished data and substudies from PROPPR and PROMMTT)
Observational studies of large numbers of patients but with only very small numbers of paediatric patients suggest that pre hospital blood is not associated with an excess of transfusion reactions and in some studies is thought to have improved survival.
Whole blood, group O, high titre neg, used in paediatrics in Pittsburgh appears to be safe with no haemolysin-mediated haemoylsis in non group O patients (Leeper et al JAMA Pediatrics 2018) ncbi.nlm.nih.gov/pmc/articles/P…