Dr Suzy Morton 🅾️➕ Profile picture
Sep 28, 2019 7 tweets 2 min read Read on X
Continuing the theme of the fortnight #Onegoal

Most O D neg blood goes to O D neg patients, but 16% is used in emergencies. Hopefully the #haemSpRs know that in this setting it is recommended only be used for people of childbearing potential, and until the blood group is known
In an emergency, group specific blood can usually be available 15-20 minutes following receipt of the (2nd) sample – depending on local SOPs. Fully cross matched blood should be available within 30-45 mins (providing the antibody screen is negative).
If the antibody screen is positive, group specific can still be issued pending antibody ID; O D neg is no safer in this scenario. Risks of transfusing need to be weighed against risks of not.
In an emergency 2 samples are still required. This might include a historic group if the patient is previously known but often in e.g. trauma 2 samples will need to be taken in quick succession.
Ideally these should be taken by different people but the key element is that the process of positive patient identification needs to be done in its entirety each time.
Group specific blood is ABO and D matched, and issued in the absence of a completed antibody screen/workup. It is just as “safe” as giving O D neg (assuming no WBIT or other errors with patient ID!).
Many hospitals have O D neg blood in satellite fridges pre issued for use in an emergency. We call these “flyers” but I don’t think anyone else does!

*Question time* #blooducation
What are the specifications for O D neg flyers?

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More from @TransfusionWM

Aug 19, 2022
I had a personal request to do a tweetorial for the #haemSpRs on haemovigilance. Here goes. A #blooducation 🧵
Haemovigilance is a systematic surveillance of adverse reactions and adverse events related to transfusion’ with the aim of improving transfusion safety.
transfusionguidelines.org/transfusion-ha…
We are very lucky in the UK to have @SHOTHV1, one of the first in the world to collate adverse events relating to transfusion - since the 1990s.
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Aug 17, 2022
This morning I met with the chair and vice chair of the Midlands Regional Transfusion Committee, the Midlands Patient Blood Management Practitioner and the Customer Services Manager. What are their roles and what does the RTC do?
A #blooducation 🧵
RTCs serve to bring together Hospital Transfusion Committees to discuss best practice, implement new guidance and provide educational resources and events. They are run by clinicians and scientists working in hospitals, supported by @NHSBT.
There are 7 RTCs in England transfusionguidelines.org/uk-transfusion… (NB map hasn’t been updated to reflect recent changes) @london_rtc @NEY_RTC @SW_RTC @SEC_RTC
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Aug 5, 2022
Teaching our incoming haematology doctors today about transfusion in haematology patients. So who needs irradiated blood and why? A #blooducation🧵
All blood in the UK is leucocyte reduced (except granulocytes, but that’s another story). Despite this, a unit of red cells or platelets can have around a million residual white cells, mostly lymphocytes.
(for the #haemSpRs, that’s < 5 x 10^6 leucocytes/unit in > 99 % of units and < 1 x 10^6 leucocytes/unit in > 90% of units, both with 95% statistical confidence)
nhsbtdbe.blob.core.windows.net/umbraco-assets…
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Aug 4, 2022
Every doctor starting in a new trust does transfusion training as part of their mandatory training. But why?
50ml ABO incompatible blood can kill a patient. ABO antibodies are naturally occurring (“everyone” has them) and they are IgM; they can activate complement and cause *immediate* intravascular haemolysis, causing release of free haem, endothelial activation, renal failure and DIC.
In most hospitals, blood banks require 2 samples (one may be historic) before releasing group specific (non-O) blood for a patient. This is to increase the chances of identifying a *wrong blood in tube* (pt whose blood's in the tube is not the pt whose details are on the outside)
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Aug 4, 2022
Transfusion tips for new #haemSpRs, a thread
As a new ST3 I remember being told to book onto the @NHSBT transfusion course learningcentre.nhsbt.nhs.uk/catalog?pagena… and wondering why I needed to learn about transfusion ... 🙈
It can be difficult to know where to start with transfusion – you can’t go on a ward round to find patients. BUT you do start with lab induction and your helpful #BMSes will show you around.
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Oct 3, 2020
Excellent session on emergency paediatric transfusion #AABB20. Cyril Jacquot talking on pre hospital transfusion and summarising the literature.
28 day mortality following haemorrhage is higher in children than adults (unpublished data and substudies from PROPPR and PROMMTT)
Observational studies of large numbers of patients but with only very small numbers of paediatric patients suggest that pre hospital blood is not associated with an excess of transfusion reactions and in some studies is thought to have improved survival.
Whole blood, group O, high titre neg, used in paediatrics in Pittsburgh appears to be safe with no haemolysin-mediated haemoylsis in non group O patients (Leeper et al JAMA Pediatrics 2018) ncbi.nlm.nih.gov/pmc/articles/P…
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