André Martin Mansoor Profile picture
Dec 14, 2019 7 tweets 4 min read Read on X
A 70 y/o man presents with new exertional dyspnea, orthopnea/PND, wide pulse pressure (~100 mm Hg), and elevated JVP. A physical finding is identified (video). Echo: preserved systolic function, no valvular disease. Thoughts? What would you do next? #PhysicalExam #cardiotwitter
Incredible discussion. Like many here I questioned the echo. Then realized Quincke's pulse = high-output state (not always AR). Sent for RHC to confirm high-output HF. Sure enough, CO was 12.5 L/min (CI 4.8 L/min/m2). Workup for cause underway. #PhysicalExam led to diagnosis. ImageImage
Physical exam was pivotal in this case. Without it, most of us would have concluded that this was "just another case of diastolic heart failure" and stopped there. Without seeing Quincke's pulse, there is no question that I would have unknowingly marched down the wrong path.
At this point thiamine deficiency (beriberi) and AV shunt are highest on my differential. Patient drinks ~2 glasses of wine/day. EtOH causes thiamine deficiency via several mechanisms, so even if patients consume a normal diet and don't appear malnourished, it is still possible. Image
Thanks @DocRock54 for asking for follow-up. The thiamine assay won't result until 12/22. If negative, then next step will be to look for shunt. I have corresponded with the authors of the excellent review below, who offered some advice about shunt workup (see image). More soon. ImageImage
UPDATE. This patient has wet beriberi. Thiamine replacement should result in total cure. Heinrich Quincke is still helping patients nearly 100 years after his death. Is that not immortality? Image
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More from @AndreMansoor

Jun 22
1/11
Una joven ingresa con epiglotitis aguda (bacteriemia por H. influenzae). Durante su hospitalización, la paciente desarrolla pancreatitis aguda y hematuria con IRA.

Un conjunto de problemas bastante confuso ¿Cómo podemos encajar todas las piezas de este rompecabezas? Image
2/11
En un paciente con hematuria, la primera pregunta que siempre hago es: ¿cuál es el origen de la sangre? ¿glomerular o no glomerular? Image
3/11
¿Cómo saber si la hemorragia es de origen glomerular o no?

Tenemos que evaluar el sedimento urinario, pero los ojos no pueden ver lo que la mente no sabe. Entonces, ¿qué estamos buscando? Image
Image
Read 11 tweets
Jun 17
1/11
A young woman is admitted with acute epiglottitis (w H flu bacteremia). While hospitalized she develops acute pancreatitis and hematuria with AKI.

A confusing constellation of problems. How can we glue this story together? Image
2/11
In a patient with hematuria, the first question I always ask is as follows: what is the source of that blood? Is it glomerular or non-glomerular? Image
3/11
How can we tell if the bleeding is glomerular or not? We have to evaluate the urine sediment. But the eyes can't see what the mind doesn't know. So what are we looking for? Image
Image
Read 11 tweets
Jun 4
1/10
A 70-year-old man presents with dyspnea. What do you notice when you first meet him?

This finding should generate a hypothesis, which we will circle back to eventually. Image
2/10
Before we do, let’s talk about dyspnea. The two main systems responsible for dyspnea are the heart and lungs. Image
3/10
The jugular venous pulse can serve as a pivot point. It can take you toward or away from the heart. With this in mind, let’s evaluate the patient’s neck. Here, he is in the upright position. (Sometimes the jugular venous pulse is better seen on the left.)
Read 10 tweets
May 14
1/16
A 30 year old man presents with tea-colored urine. Image
2/16
Our instinct is to consult the framework for hematuria: Image
3/16
Then we realize that while the color of the urine could absolutely be consistent with hematuria, there are mimics of hematuria that should be considered as well. Image
Read 15 tweets
Apr 21
1/13
A man is admitted with acute abdominal pain, nausea, vomiting, and diarrhea. HR 130, BP 90/52.

You walk into the room to meet the patient. What do you notice? This should generate at least one hypothesis. Image
2/13
You ask him for an old photo for comparison. His wife pulls out her phone and produces this picture (B) taken about 10 years prior.

Pt reports darkening of skin over an 8 year period (for which he saw several clinicians). What conditions are you considering? Image
3/13
Let’s first consider the hypotension. Image
Read 13 tweets
Apr 9
1/
A middle-aged man presents with acute sudden-onset dyspnea and hypotension. He is sitting upright.

What do you notice? Let’s see if we can figure out the cause of hypotension.
2/
First.

What are the 4 basic mechanisms of hypotension?

Hypotension can be hypovolemic, cardiogenic, distributive, or obstructive. Image
3/
Hypovolemic hypotension occurs because of a decrease in preload. The pump is ready, the blood vessels are ready, but the "ammunition" is not there. JVP low, extremities cool.

2 arrows down for CVP/JVP since that is the primary issue. Image
Image
Read 20 tweets

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