André Martin Mansoor Profile picture
Dec 14, 2019 7 tweets 4 min read Read on X
A 70 y/o man presents with new exertional dyspnea, orthopnea/PND, wide pulse pressure (~100 mm Hg), and elevated JVP. A physical finding is identified (video). Echo: preserved systolic function, no valvular disease. Thoughts? What would you do next? #PhysicalExam #cardiotwitter
Incredible discussion. Like many here I questioned the echo. Then realized Quincke's pulse = high-output state (not always AR). Sent for RHC to confirm high-output HF. Sure enough, CO was 12.5 L/min (CI 4.8 L/min/m2). Workup for cause underway. #PhysicalExam led to diagnosis. ImageImage
Physical exam was pivotal in this case. Without it, most of us would have concluded that this was "just another case of diastolic heart failure" and stopped there. Without seeing Quincke's pulse, there is no question that I would have unknowingly marched down the wrong path.
At this point thiamine deficiency (beriberi) and AV shunt are highest on my differential. Patient drinks ~2 glasses of wine/day. EtOH causes thiamine deficiency via several mechanisms, so even if patients consume a normal diet and don't appear malnourished, it is still possible. Image
Thanks @DocRock54 for asking for follow-up. The thiamine assay won't result until 12/22. If negative, then next step will be to look for shunt. I have corresponded with the authors of the excellent review below, who offered some advice about shunt workup (see image). More soon. ImageImage
UPDATE. This patient has wet beriberi. Thiamine replacement should result in total cure. Heinrich Quincke is still helping patients nearly 100 years after his death. Is that not immortality? Image
Image

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with André Martin Mansoor

André Martin Mansoor Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @AndreMansoor

Nov 12
1/9
A 33 y/o F with carpal tunnel syndrome presents with polyuria and polydipsia. She has a fasting serum glucose of 212 mg/dL and a hemoglobin a1c of 9.7%.

Do you have an approach to hyperglycemia? Image
2/9
The first step is to determine whether we are dealing with insulin-dependent hyperglycemia or insulin-independent hyperglycemia. Image
3/9
Insulin-dependent hyperglycemia occurs as a result of insulin deficiency; insulin-independent hyperglycemia occurs despite the presence of insulin and is primarily the result of insulin resistance. Image
Read 10 tweets
Nov 1
1/10
A young man presents with hematuria and is found to have these painful skin lesions on physical exam. Image
Image
2/10
In a patient with hematuria, the first question I always ask is: what is the source of that blood?

Is it glomerular or non-glomerular? Image
3/10
How can we tell if the bleeding is glomerular or not? We have to evaluate the urine sediment. But the eyes can’t see what the mind doesn’t know. So what are we looking for?

(Images courtesy of @OHSUNephrology) Image
Read 11 tweets
Oct 24
1/9
A man presents with weakness.

Let’s walk through an approach to this problem. Image
2/9
The etiologies of weakness can be subdivided into 4 main categories: Image
3/9
What are the signs of an UMN lesion?

No (or minimal) muscle atrophy, no fasciculations, increased tone, + Babinski’s, and increased reflexes, the latter of which is demonstrated below in a different patient with a L-sided stroke.
Read 9 tweets
Oct 14
1/10
A 76 y/o man presents with swallowing difficulty.

So why are we looking at his hands? Image
2/10
What’s your approach to dysphagia?

The first thing we want to determine is whether dysphagia is oropharyngeal or esophageal. Image
3/10
The patient not have trouble initiating a swallow and there is no choking, coughing, or drooling. Food material seems to get stuck in the middle of his chest.

These features point away from oropharyngeal dysphagia and toward esophageal dysphagia. Image
Read 10 tweets
Aug 14
1/11
A physical exam SMASLAR in 11 tweets.

This middle-age patient was admitted several weeks ago with cardiogenic shock of unclear etiology. He is recovering well on the ward when I meet him. This is what I see:
2/11
Here's another view of these vigorous carotid pulses (Corrigan's pulse). Classically associated with aortic regurgitation (like we saw 2 weeks ago), there are several other causes:

1. High-output state (eg, wet beriberi) like we saw last week
2. Coarctation of the aorta
3/11
I immediately think he must have aortic regurgitation. I listen, but I don't hear a diastolic murmur.

Still, I evaluate his nail beds and this is what I see:
Read 12 tweets
Aug 10
1/11
A man presents to you with the clinical syndrome of heart failure (weight gain, orthopnea, elevated JVP, etc.). BP is 144/48 mm Hg.

Wide pulse pressure suggests aortic regurgitation (like our case last week). So you look for other physical findings. What do you notice?
2/11
Quincke’s pulse is consistent with your hypothesis, so you look for more evidence in his neck. And you have found it.

Corrigan's pulse:
3/11
You then listen to the patient’s heart in anticipation of hearing a decrescendo diastolic murmur and confirming your suspicions.
Read 11 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(